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    DIP-epsilon Dpr-interacting protein epsilon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIP-epsilonprovided by FlyBase
    Official Full Name
    Dpr-interacting protein epsilonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259714
    Locus tag
    Dmel_CG42368
    See related
    AllianceGenome:FB:FBgn0259714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    42368; CG13981; CG33295; CG42368; CG9508; CG9511; DIPepsilon; Dmel\CG42368
    Old locus tag
    Dmel_CG9508; Dmel_CG9511
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including CNS surface glial cell; adult head; glomerulus; optic lobe intrinsic neurons; and presumptive arista. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DIP-epsilon in Genome Data Viewer
    Location:
    26C4-26D1; 2-20 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6377771..6411326, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6377771..6411326, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Neprilysin-like 4 Neighboring gene slow as molasses Neighboring gene Neprilysin-like 5 Neighboring gene Neprilysin-like 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tiggrin Neighboring gene Fic domain-containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners. Xu C, et al. Neuron, 2019 Sep 4. PMID 31300277, Free PMC Article
    2. Neuronal machinery of sleep homeostasis in Drosophila. Donlea JM, et al. Neuron, 2014 Feb 19. PMID 24559676, Free PMC Article
    3. Targeting expression to projection neurons that innervate specific mushroom body calyx and antennal lobe glomeruli in larval Drosophila. Masuda-Nakagawa LM, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20659588
    4. A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila. Sun X, et al. Cell Rep, 2014 Sep 25. PMID 25220459, Free PMC Article
    5. Function and dynamics of slam in furrow formation in early Drosophila embryo. Acharya S, et al. Dev Biol, 2014 Feb 15. PMID 24368071

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dpr-interacting protein epsilon
    Names
    CG42368-PA
    DIP-epsilon-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6377771..6411326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144327.2 → NP_001137799.1  Dpr-interacting protein epsilon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ70
      Conserved Domains (4) summary
      cd00096
      Location:69 → 139
      Ig; Immunoglobulin domain
      smart00408
      Location:172 → 237
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:165 → 249
      IG_like; Immunoglobulin like
      cl11960
      Location:270 → 339
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4IJ70 A4IJ70

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