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    Ir52a Ionotropic receptor 52a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36715, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ir52aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 52aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034023
    Locus tag
    Dmel_CG12960
    See related
    AllianceGenome:FB:FBgn0034023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    52a; CG12960; DmelIR52a; Dmel\CG12960; IR52a
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult gustatory receptor neurons; appendage; leg mechanosensory bristle; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir52a in Genome Data Viewer
    Location:
    52A6-52A6; 2-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15499632..15501431)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11387137..11388936)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 52b Neighboring gene Ionotropic receptor 52c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sex Mysteries of the Fly Courtship Master Regulator Fruitless. Sato K, et al. Front Behav Neurosci, 2019. PMID 31680899, Free PMC Article
    2. Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster. Dhakal S, et al. Commun Biol, 2021 Nov 12. PMID 34773080, Free PMC Article
    3. Calcium Taste Avoidance in Drosophila. Lee Y, et al. Neuron, 2018 Jan 3. PMID 29276056, Free PMC Article
    4. Candidate ionotropic taste receptors in the Drosophila larva. Stewart S, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25825777, Free PMC Article
    5. Mechanism of Acetic Acid Gustatory Repulsion in Drosophila. Rimal S, et al. Cell Rep, 2019 Feb 5. PMID 30726729, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Optogenetic activation of IR52a+ neurons in the wing activates second-order projections in the subesophageal zone.
      Title: Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 52a
    Names
    CG12960-PB
    Ir52a-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15499632..15501431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137197.2 → NP_611041.2  ionotropic receptor 52a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611041.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A077DCM6, A1ZA14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA14 A1ZA14

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