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    eIF2Bdelta eukaryotic translation initiation factor 2B subunit delta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37706, updated on 9-Dec-2024

    Summary

    Official Symbol
    eIF2Bdeltaprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 2B subunit deltaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034858
    Locus tag
    Dmel_CG10315
    See related
    AllianceGenome:FB:FBgn0034858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10315; Dmel\CG10315; eIF2B-delta
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic/larval midgut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See eIF2Bdelta in Genome Data Viewer
    Location:
    59D9-59D10; 2-102 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23386521..23389052)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19274044..19276575)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44784 Neighboring gene uncharacterized protein Neighboring gene reduction of Rh1 Neighboring gene Myotubularin related protein 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in translational initiation PubMed 
    Component Evidence Code Pubs
    located_in cytosol PubMed 
    part_of eukaryotic translation initiation factor 2B complex PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2B subunit delta
    Names
    CG10315-PA
    CG10315-PB
    CG10315-PC
    CG10315-PD
    eIF2B-delta
    eIF2Bdelta-PA
    eIF2Bdelta-PB
    eIF2Bdelta-PC
    eIF2Bdelta-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23386521..23389052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137946.4 → NP_611790.1  eukaryotic translation initiation factor 2B subunit delta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L6, Q9W1Q8
      Related
      FBpp0071923
      Conserved Domains (2) summary
      COG1184
      Location:306 → 619
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:323 → 611
      IF-2B; Initiation factor 2 subunit family
    2. NM_001169794.2 → NP_001163265.1  eukaryotic translation initiation factor 2B subunit delta, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X6, Q494L6
      Conserved Domains (2) summary
      COG1184
      Location:256 → 569
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:273 → 561
      IF-2B; Initiation factor 2 subunit family
    3. NM_166602.3 → NP_726321.1  eukaryotic translation initiation factor 2B subunit delta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X6, Q494L6
      Related
      FBpp0071922
      Conserved Domains (2) summary
      COG1184
      Location:256 → 569
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:273 → 561
      IF-2B; Initiation factor 2 subunit family
    4. NM_166601.2 → NP_726320.1  eukaryotic translation initiation factor 2B subunit delta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X6, Q494L6
      Related
      FBpp0071924
      Conserved Domains (2) summary
      COG1184
      Location:256 → 569
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:273 → 561
      IF-2B; Initiation factor 2 subunit family
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