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    Trm1 tRNA methyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34656, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trm1provided by FlyBase
    Official Full Name
    tRNA methyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032430
    Locus tag
    Dmel_CG6388
    See related
    AllianceGenome:FB:FBgn0032430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6388; Dmel\CG6388; TRM1
    Summary
    Enables tRNA (guanine(26)-N2)-dimethyltransferase activity. Involved in tRNA N2-guanine methylation. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; hindgut proper primordium; larval muscle system; and somatic muscle primordium. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trm1 in Genome Data Viewer
    Location:
    33E4-33E4; 2-46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12428028..12430021)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12428028..12430021)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Fam92 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SR family splicing factor SC35 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants. Funk HM, et al. PLoS One, 2020. PMID 33253256, Free PMC Article
    2. Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Wirbelauer C, et al. Genes Dev, 2005 Aug 1. PMID 16077006, Free PMC Article
    3. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. Bell O, et al. EMBO J, 2007 Dec 12. PMID 18007591, Free PMC Article
    4. Drosophila growth and development in the absence of dMyc and dMnt. Pierce SB, et al. Dev Biol, 2008 Mar 15. PMID 18241851, Free PMC Article
    5. PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. Ciurciu A, et al. PLoS Genet, 2013 Oct. PMID 24204300, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2)-dimethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA (guanine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA N2-guanine methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methyltransferase 1
    Names
    CG6388-PA
    Trm1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12428028..12430021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135722.4 → NP_609566.1  tRNA methyltransferase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VK89
      Related
      FBpp0079949
      Conserved Domains (2) summary
      pfam08576
      Location:58 → 103
      DUF1764; Eukaryotic protein of unknown function (DUF1764)
      cl17173
      Location:17 → 452
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK89.1 Q9VK89

    Gene LinkOut

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    Chemical Information
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