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    Treh Trehalase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45368, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Trehprovided by FlyBase
    Official Full Name
    Trehalaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003748
    Locus tag
    Dmel_CG9364
    See related
    AllianceGenome:FB:FBgn0003748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    87D3T; anon-EST:Posey159; anon-sts38; CG9364; Dmel\CG9364; DmTre; ESTS:87D3T; FBgn0003748; Tre; TRE; treh; TREH
    Summary
    Enables alpha,alpha-trehalase activity. Involved in trehalose catabolic process. Located in cytosol and extracellular space. Is expressed in several structures, including adult head; adult heart; epithelium; larval somatic muscle cell; and neurohemal organ. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Treh in Genome Data Viewer
    Location:
    57B16-57B19; 2-92 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21074018..21088945)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16961523..16976450)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44703 Neighboring gene antisense RNA:CR44704 Neighboring gene Chitinase 9 Neighboring gene uncharacterized protein Neighboring gene Rabaptin-5 Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein Neighboring gene king tubby Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and biochemical aspects of trehalase from Drosophila melanogaster. Oliver MJ, et al. Biochem Genet, 1978 Oct. PMID 105719
    2. Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe. Chen X, et al. PLoS One, 2014. PMID 25003205, Free PMC Article
    3. Molecular cloning and in silico studies of physiologically significant trehalase from Drosophila melanogaster. Shukla E, et al. Int J Biol Macromol, 2016 Nov. PMID 27377458
    4. Stress-related hormones affect carbohydrate metabolism in Drosophila females. Karpova EK, et al. Arch Insect Biochem Physiol, 2019 May. PMID 30793357
    5. Trehalase polymorphism in Drosophila melanogaster. Burton RS, et al. Biochem Genet, 1986 Oct. PMID 3096311

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both Tps1 and Treh mutant larvae exhibit a high lethality after desiccation stress. These results demonstrate that the regulation of trehalose metabolism is essential for normal development, body water homeostasis, and desiccation tolerance in Drosophila.
      Title: Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis.
    2. The present study holds significance in understanding the structural aspects of Drosophila trehalase in spite of unavailabilty of eukaryotic trehalase crystal structure.
      Title: Molecular cloning and in silico studies of physiologically significant trehalase from Drosophila melanogaster.
    3. Treh plays a role in neuroepithelial stem cell maintenance and differentiation during Drosophila optic lobe development.
      Title: Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha,alpha-trehalase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha,alpha-trehalase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in trehalose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trehalase
    Names
    CG9364-PA
    CG9364-PB
    CG9364-PC
    CG9364-PD
    CG9364-PE
    CG9364-PF
    CG9364-PG
    Treh-PA
    Treh-PB
    Treh-PC
    Treh-PD
    Treh-PE
    Treh-PF
    Treh-PG
    NP_001261115.1
    NP_524821.1
    NP_726023.1
    NP_726024.1
    NP_726025.1
    NP_726026.1
    NP_726027.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21074018..21088945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166422.2 → NP_726024.1  trehalase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZR3, A5XCQ4
      Related
      FBpp0071464
      Conserved Domains (1) summary
      pfam01204
      Location:35 → 541
      Trehalase; Trehalase

    2. NM_001274186.1 → NP_001261115.1  trehalase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261115.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZR3, A5XCQ4
      Conserved Domains (1) summary
      pfam01204
      Location:35 → 541
      Trehalase; Trehalase

    3. NM_080082.3 → NP_524821.1  trehalase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZR3, A5XCQ4
      Related
      FBpp0071465
      Conserved Domains (1) summary
      pfam01204
      Location:35 → 541
      Trehalase; Trehalase

    4. NM_166421.2 → NP_726023.1  trehalase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZR3, A5XCQ4
      Related
      FBpp0071466
      Conserved Domains (1) summary
      pfam01204
      Location:35 → 541
      Trehalase; Trehalase

    5. NM_166423.3 → NP_726025.1  trehalase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E903, Q0E904, Q7YWL2, Q961P0, Q9W2M1, Q9W2M2, Q9W2M3
      UniProtKB/TrEMBL
      A5XCQ1, A5XCQ4, A5XCQ9
      Related
      FBpp0071468
      Conserved Domains (1) summary
      pfam01204
      Location:71 → 577
      Trehalase; Trehalase

    6. NM_166425.2 → NP_726027.1  trehalase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5XCQ4
      Related
      FBpp0071467
      Conserved Domains (1) summary
      pfam01204
      Location:1 → 496
      Trehalase; Trehalase

    7. NM_166424.2 → NP_726026.1  trehalase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726026.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E903, Q0E904, Q7YWL2, Q961P0, Q9W2M1, Q9W2M2, Q9W2M3
      UniProtKB/TrEMBL
      A5XCQ1, A5XCQ4, A5XCQ9
      Related
      FBpp0071469
      Conserved Domains (1) summary
      pfam01204
      Location:71 → 577
      Trehalase; Trehalase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4UZR3 A4UZR3
    Q9W2M2.1 Q9W2M2

    Gene LinkOut

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