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    poe purity of essence [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46243, updated on 17-Dec-2024

    Summary

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    Official Symbol
    poeprovided by FlyBase
    Official Full Name
    purity of essenceprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011230
    Locus tag
    Dmel_CG14472
    See related
    AllianceGenome:FB:FBgn0011230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3420; calo; Calo; CG14472; Dmel\CG14472; ms(2)01659; ms(2)27C; ms(2)3420; ms(2)5970; Poe; POE; POE/UBR4; POE_DROME; push; Ubr4; UBR4
    Summary
    Enables calmodulin binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; perineurial glial growth; and positive regulation of male gonad development. Located in P granule. Is expressed in adult head; imaginal disc; larval brain; and spermatozoon. Used to study intellectual disability. Orthologous to human UBR4 (ubiquitin protein ligase E3 component n-recognin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See poe in Genome Data Viewer
    Location:
    28D11-28E1; 2-30 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8054322..8071624, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8054322..8071624, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Coiled-coil domain containing 53 Neighboring gene Ribosomal protein L36A Neighboring gene Multiple EGF like domains 8 Neighboring gene Mediator complex subunit 20 Neighboring gene TBP-related factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UBR4 deficiency causes male sterility and testis abnormal in Drosophila. Xie SM, et al. Front Endocrinol (Lausanne), 2023. PMID 37529615, Free PMC Article
    2. Mutations in the Drosophila pushover gene confer increased neuronal excitability and spontaneous synaptic vesicle fusion. Richards S, et al. Genetics, 1996 Apr. PMID 8846899, Free PMC Article
    3. Development and organization of the Drosophila olfactory system: an analysis using enhancer traps. Riesgo-Escovar J, et al. J Neurobiol, 1992 Oct. PMID 1334133
    4. FMRP-dependent production of large dosage-sensitive proteins is highly conserved. Flanagan K, et al. Genetics, 2022 Jul 30. PMID 35731217, Free PMC Article
    5. wde, calpA, if, dap160, and poe genes knock down Drosophila models exhibit neurofunctional deficit. Haddadi M, et al. Gene, 2022 Jun 30. PMID 35447243

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging.
      Title: Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging.
    2. A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice.
      Title: A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice.
    3. In the presence of USP47, MAPK would be stabilized as USP47 acts to deubiquitinate MAPK, thus counteracting the direct ubiquitination of MAPK by POE/UBR4 activity.
      Title: The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glial cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in perineurial glial growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in perineurial glial growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    purity of essence
    Names
    CG14472-PA
    CG14472-PB
    calossin
    male sterile(2)27C
    male sterile(2)3420
    poe-PA
    poe-PB
    pushover

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8054322..8071624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057638.4 → NP_476986.1  purity of essence, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96958, Q8MS98, Q9VLT5, Q9XYD1, Q9XYD2
      UniProtKB/TrEMBL
      M9PB68
      Related
      FBpp0079167
      Conserved Domains (3) summary
      smart00396
      Location:1794 → 1862
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      pfam12773
      Location:3793 → 3837
      DZR; Double zinc ribbon
      pfam13764
      Location:4493 → 5296
      E3_UbLigase_R4; E3 ubiquitin-protein ligase UBR4

    2. NM_001273293.1 → NP_001260222.1  purity of essence, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96958, Q8MS98, Q9VLT5, Q9XYD1, Q9XYD2
      UniProtKB/TrEMBL
      M9PB68
      Conserved Domains (3) summary
      smart00396
      Location:1794 → 1862
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      pfam12773
      Location:3793 → 3837
      DZR; Double zinc ribbon
      pfam13764
      Location:4493 → 5296
      E3_UbLigase_R4; E3 ubiquitin-protein ligase UBR4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB68 M9PB68
    Q9VLT5.1 Q9VLT5

    Gene LinkOut

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