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    AsnS Asparagine synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AsnSprovided by FlyBase
    Official Full Name
    Asparagine synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0270926
    Locus tag
    Dmel_CG33486
    See related
    AllianceGenome:FB:FBgn0270926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AS; asparagine-synthetase; CG33486; Dmel\CG33486
    Summary
    Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AsnS in Genome Data Viewer
    Location:
    78C1-78C2; 3-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21173118..21174973)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21166218..21168073)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene uncharacterized protein Neighboring gene Adenylyl cyclase 78C Neighboring gene chromosome bows Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene parkin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster. Inoue YH, et al. J Cell Biol, 2000 Apr 3. PMID 10747094, Free PMC Article
    2. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378
    3. Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila. Boomgarden AC, et al. BMC Genomics, 2019 Jan 7. PMID 30616504, Free PMC Article
    4. Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase. Bu S, et al. Cell Rep, 2022 May 31. PMID 35649352
    5. Mating alters gene expression patterns in Drosophila melanogaster male heads. Ellis LL, et al. BMC Genomics, 2010 Oct 11. PMID 20937114, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables asparagine synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparagine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    asparagine synthetase
    Names
    AsnS-PA
    CG33486-PA
    asparagine-synthetase
    NP_996132.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21173118..21174973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206410.2 → NP_996132.1  asparagine synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTW9
      Conserved Domains (3) summary
      PRK09431
      Location:1 → 554
      asnB; asparagine synthetase B; Provisional
      cd00712
      Location:2 → 182
      AsnB; Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a ...
      pfam00733
      Location:225 → 528
      Asn_synthase; Asparagine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTW9 Q7KTW9

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