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    p130CAS p130CAS [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    p130CASprovided by FlyBase
    Official Full Name
    p130CASprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035101
    Locus tag
    Dmel_CG1212
    See related
    AllianceGenome:FB:FBgn0035101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1212; CT1293; Dcas; DCas; Dmel\CG1212; p130cas; p130Cas
    Summary
    Involved in axonal defasciculation; cell-cell adhesion; and maintenance of cell polarity. Predicted to be located in focal adhesion. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; dorsal ectoderm; dorsal thoracic disc; and ventral nerve cord. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to several human genes including BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See p130CAS in Genome Data Viewer
    Location:
    61B1-61B2; 3-1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (152884..174517)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (152884..174517)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dynein intermediate chain at 61B Neighboring gene long non-coding RNA:CR43151 Neighboring gene antisense RNA:CR45806 Neighboring gene uncharacterized protein Neighboring gene Vitamin D[[3]] up-regulated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. Camacho Leal Mdel P, et al. Gene, 2015 May 10. PMID 25727852, Free PMC Article
    2. Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development. Huang Z, et al. Development, 2007 Jun. PMID 17537798
    3. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Dourlen P, et al. Mol Psychiatry, 2017 Jun. PMID 27113998, Free PMC Article
    4. Induction of focal adhesions and motility in Drosophila S2 cells. Ribeiro SA, et al. Mol Biol Cell, 2014 Dec 1. PMID 25273555, Free PMC Article
    5. Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. Dourlen P, et al. Curr Genet Med Rep, 2018. PMID 30147999, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCAR1 has a pivotal role in the regulation of tissue homeostasis and morphogeneis. (Review)
      Title: p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis.
    2. p130CAS signaling protein functions with integrins to specify axon guidance during development.
      Title: Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 164030-164149 mobile_element_type = transposon:INE-1{}3913

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in axonal defasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    p130CAS
    Names
    CG1212-PB
    CG1212-PD
    CG1212-PE
    CG1212-PF
    CG1212-PG
    p130CAS-PB
    p130CAS-PD
    p130CAS-PE
    p130CAS-PF
    p130CAS-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      152884..174517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103986.3 → NP_001097456.2  p130CAS, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097456.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ58, A8JNG5
      Conserved Domains (3) summary
      cd11549
      Location:434 → 596
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cd11844
      Location:81 → 136
      SH3_CAS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding proteins
      pfam12026
      Location:612 → 817
      DUF3513; Domain of unknown function (DUF3513)

    2. NM_001169831.3 → NP_001163302.1  p130CAS, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVE5
      Conserved Domains (3) summary
      cd11549
      Location:396 → 558
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cd11844
      Location:43 → 98
      SH3_CAS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding proteins
      pfam12026
      Location:574 → 779
      DUF3513; Domain of unknown function (DUF3513)

    3. NM_167797.3 → NP_728478.1  p130CAS, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U71, Q9W0U7, Q9W0U8
      Related
      FBpp0072377
      Conserved Domains (2) summary
      cd11549
      Location:171 → 333
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      pfam12026
      Location:349 → 554
      DUF3513; Domain of unknown function (DUF3513)

    4. NM_001144389.2 → NP_001137861.1  p130CAS, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U71, Q9W0U7, Q9W0U8
      Conserved Domains (2) summary
      cd11549
      Location:171 → 333
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      pfam12026
      Location:349 → 554
      DUF3513; Domain of unknown function (DUF3513)

    5. NM_001144388.2 → NP_001137860.1  p130CAS, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0H1
      Conserved Domains (2) summary
      cd11549
      Location:170 → 332
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      pfam12026
      Location:348 → 553
      DUF3513; Domain of unknown function (DUF3513)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4IJ58 A4IJ58
    B7Z0H1 B7Z0H1
    Q7KVE5 Q7KVE5
    Q95U71 Q95U71

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