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    Dhps Deoxyhypusine synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhpsprovided by FlyBase
    Official Full Name
    Deoxyhypusine synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035854
    Locus tag
    Dmel_CG8005
    See related
    AllianceGenome:FB:FBgn0035854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8005; dhs; Dmel\CG8005
    Summary
    Enables deoxyhypusine synthase activity. Involved in negative regulation of reactive oxygen species metabolic process and protein modification process. Predicted to be active in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhps in Genome Data Viewer
    Location:
    66B12-66B12; 3-22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8198207..8199491)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8191307..8192591)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 24 Neighboring gene uncharacterized protein Neighboring gene NEDD8-conjugating enzyme UbcE2M Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Functional analysis of CG8005 gene in Drosophila testis]. Chen WY, et al. Yi Chuan, 2020 Nov 20. PMID 33229318
    2. Effects of N-acetylcysteine on CG8005 gene-mediated proliferation and apoptosis of Drosophila S2 embryonic cells. Chen W, et al. Sci Rep, 2023 Aug 2. PMID 37532734, Free PMC Article
    3. eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. Liang Y, et al. Cell Rep, 2021 Apr 13. PMID 33852845
    4. CG8005 Mediates Transit-Amplifying Spermatogonial Divisions via Oxidative Stress in Drosophila Testes. Chen W, et al. Oxid Med Cell Longev, 2020. PMID 33193998, Free PMC Article
    5. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of N-acetylcysteine on CG8005 gene-mediated proliferation and apoptosis of Drosophila S2 embryonic cells.
      Title: Effects of N-acetylcysteine on CG8005 gene-mediated proliferation and apoptosis of Drosophila S2 embryonic cells.
    2. CG8005 Mediates Transit-Amplifying Spermatogonial Divisions via Oxidative Stress in Drosophila Testes.
      Title: CG8005 Mediates Transit-Amplifying Spermatogonial Divisions via Oxidative Stress in Drosophila Testes.
    3. [Functional analysis of CG8005 gene in Drosophila testis].
      Title: [Functional analysis of CG8005 gene in Drosophila testis].
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deoxyhypusine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyhypusine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein modification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    deoxyhypusine synthase
    Names
    CG8005-PA
    CG8005-PB
    Dhps-PA
    Dhps-PB
    NP_001261569.1
    NP_648188.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8198207..8199491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139931.3 → NP_648188.2  deoxyhypusine synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648188.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VSF4
      Related
      FBpp0076418
      Conserved Domains (1) summary
      pfam01916
      Location:40 → 346
      DS; Deoxyhypusine synthase

    2. NM_001274640.1 → NP_001261569.1  deoxyhypusine synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEZ0
      Conserved Domains (1) summary
      cl00826
      Location:8 → 58
      DS; Deoxyhypusine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEZ0 M9PEZ0
    Q9VSF4.2 Q9VSF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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