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    Sln Silnoon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36263, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Slnprovided by FlyBase
    Official Full Name
    Silnoonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033657
    Locus tag
    Dmel_CG8271
    See related
    AllianceGenome:FB:FBgn0033657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8271; Dmel\CG8271
    Summary
    Enables monocarboxylic acid transmembrane transporter activity. Involved in import across plasma membrane; monocarboxylic acid transport; and neuron cellular homeostasis. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in adult head; eye disc; organism; and wing disc. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to several human genes including SLC16A12 (solute carrier family 16 member 12) and SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sln in Genome Data Viewer
    Location:
    48C4-48C5; 2-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11845324..11852324)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7732829..7739829)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44304 Neighboring gene site-2 protease Neighboring gene uncharacterized protein Neighboring gene Megator Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. Jang C, et al. J Cell Biol, 2008 Oct 6. PMID 18838551, Free PMC Article
    2. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Matthews KA, et al. Genetics, 2009 Jan. PMID 19015545, Free PMC Article
    3. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
    4. A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation. Gándara L, et al. Sci Rep, 2019 Dec 27. PMID 31882718, Free PMC Article
    5. Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila. Rabah Y, et al. Nat Metab, 2023 Nov. PMID 37932430, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monocarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monocarboxylic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monocarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monocarboxylic acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    silnoon
    Names
    CG8271-PA
    Sln-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11845324..11852324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136862.2 → NP_610706.1  silnoon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U154
      Related
      FBpp0087139
      Conserved Domains (2) summary
      cd06174
      Location:656 → 827
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:658 → 847
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U154 Q5U154

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