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    CCDC53 Coiled-coil domain containing 53 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCDC53provided by FlyBase
    Official Full Name
    Coiled-coil domain containing 53provided by FlyBase
    Primary source
    FLYBASE:FBgn0031979
    Locus tag
    Dmel_CG7429
    See related
    AllianceGenome:FB:FBgn0031979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ccdc53; Ccdc53; CG7429; Dmel\CG7429
    Summary
    Involved in nuclear envelope budding and positive regulation of cell adhesion. Located in nucleoplasm. Part of WASH complex. Colocalizes with nuclear envelope. Is expressed in organism. Orthologous to human WASHC3 (WASH complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCDC53 in Genome Data Viewer
    Location:
    28D3-28D3; 2-29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8041106..8041879)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8041106..8041879)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene barrier to autointegration factor Neighboring gene Connector of kinase to AP-1 Neighboring gene ncRNA Neighboring gene Ribosomal protein L36A Neighboring gene Multiple EGF like domains 8 Neighboring gene purity of essence

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding. Davidson KA, et al. J Cell Biol, 2023 Aug 7. PMID 37163553, Free PMC Article
    2. Evolutionary conservation of the WASH complex, an actin polymerization machine involved in endosomal fission. Derivery E, et al. Commun Integr Biol, 2010 May. PMID 20714399, Free PMC Article
    3. Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis. Verboon JM, et al. J Cell Sci, 2018 Apr 13. PMID 29549166, Free PMC Article
    4. Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization. Nagel BM, et al. J Cell Sci, 2017 Jan 15. PMID 27884932
    5. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Jia D, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498093, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope budding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of WASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of WASH complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    colocalizes_with nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Coiled-coil domain containing 53
    Names
    CCDC53-PA
    CG7429-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8041106..8041879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135334.5 → NP_609178.1  Coiled-coil domain containing 53 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609178.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYM1, Q9VLT8
      Related
      FBpp0079162
      Conserved Domains (1) summary
      pfam10152
      Location:28 → 164
      DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLT8.2 Q9VLT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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