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    Ir52b Ionotropic receptor 52b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246631, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ir52bprovided by FlyBase
    Official Full Name
    Ionotropic receptor 52bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050469
    Locus tag
    Dmel_CG30469
    See related
    AllianceGenome:FB:FBgn0050469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    52b; CG12961; CG30469; DmelIR52b; Dmel\CG30469; IF52b; IR52b
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in mesothoracic leg taste bristle chemosensory neurons; metathoracic leg taste bristle chemosensory neurons; prothoracic leg taste bristle chemosensory neurons; and wing. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir52b in Genome Data Viewer
    Location:
    52A6-52A6; 2-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15501820..15503610)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11389325..11391115)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 52a Neighboring gene Ionotropic receptor 52c Neighboring gene Ionotropic receptor 52d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila IR20a clade of ionotropic receptors are candidate taste and pheromone receptors. Koh TW, et al. Neuron, 2014 Aug 20. PMID 25123314, Free PMC Article
    2. A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster. Sang J, et al. Elife, 2024 Apr 4. PMID 38573740, Free PMC Article
    3. A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development. Hopkins BR, et al. PLoS Biol, 2023 Jun. PMID 37379332, Free PMC Article
    4. Avoiding cantharidin through ionotropic receptors. Pradhan RN, et al. J Hazard Mater, 2024 Mar 15. PMID 38278077
    5. A Molecular and Cellular Context-Dependent Role for Ir76b in Detection of Amino Acid Taste. Ganguly A, et al. Cell Rep, 2017 Jan 17. PMID 28099851, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 52b
    Names
    CG30469-PB
    Ir52b-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15501820..15503610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166097.2 → NP_725469.2  ionotropic receptor 52b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725469.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA15 A1ZA15

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