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    pzg putzig [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pzgprovided by FlyBase
    Official Full Name
    putzigprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259785
    Locus tag
    Dmel_CG7752
    See related
    AllianceGenome:FB:FBgn0259785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7752; Dmel\CG7752; p160; Pzg; Pzg/Z4; Q9VP57_DROME; z4; Z4
    Summary
    Enables chromatin binding activity; nuclear receptor binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; positive regulation of mitotic cell cycle; and regulation of signal transduction. Located in chromosome and nucleus. Is expressed in several structures, including adult head; adult heart; antennal anlage; ganglia; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See pzg in Genome Data Viewer
    Location:
    78C5-78C6; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21286099..21290310)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21279199..21283410)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pumpless Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 78Ca Neighboring gene Cuticular protein 78Cb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization. Puerto M, et al. Nucleic Acids Res, 2024 Jun 10. PMID 38520405, Free PMC Article
    2. The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters. Melnikova LS, et al. Dokl Biochem Biophys, 2020 Jan. PMID 32342309
    3. The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster. Silva-Sousa R, et al. PLoS Genet, 2012. PMID 23271984, Free PMC Article
    4. The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster. Melnikova LS, et al. Dokl Biochem Biophys, 2021 May. PMID 34189647
    5. The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART. Silva-Sousa R, et al. Mob DNA, 2013 Jul 3. PMID 23822164, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster.
      Title: The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster.
    2. The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters.
      Title: The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters.
    3. Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.
      Title: Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.
    4. downregulation of pzg activity in the developing wing imaginal discs induces an apoptotic response.
      Title: Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.
    5. JIL-1 and Z4 (also known as Putzig), which are necessary for establishing a fine-tuned regulation of the transcription of the major component of Drosophila telomeres, the HeT-A retrotransposon, thus guaranteeing genome stability
      Title: The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster.
    6. Chriz and Z4 form a complex that recruits the JIL-1 kinase to polytene chromosomes, enabling local H3S10 phosphorylation of interband nucleosomal histones.
      Title: The Chriz-Z4 complex recruits JIL-1 to polytene chromosomes, a requirement for interband-specific phosphorylation of H3S10.
    7. Pzg is associated with EcR in vivo and required for the transcriptional induction of EcR target genes, whereas reduced ecdysteroid levels imply a NURF-independent function of Pzg.
      Title: The Putzig-NURF nucleosome remodeling complex is required for ecdysone receptor signaling and innate immunity in Drosophila melanogaster.
    8. These data suggest a novel Putzig-nuclear remodeling factor chromatin complex required for epigenetic activation of Notch targets.
      Title: A novel Pzg-NURF complex regulates Notch target gene activity.
    9. These findings uncover different modes of operation of Putzig (pzg) during imaginal development of Drosophila, and they provide a novel mechanism of Notch regulation.
      Title: putzig is required for cell proliferation and regulates notch activity in Drosophila.
    10. involved in the higher-order structuring of chromosomes
      Title: Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ecdysone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putzig
    Names
    CG7752-PA
    CG7752-PB
    Z4
    pzg-PA
    pzg-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21286099..21290310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141040.2 → NP_649297.1  putzig, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP57
      Related
      FBpp0077992
      Conserved Domains (4) summary
      sd00017
      Location:360 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:268 → 289
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:373 → 399
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:375 → 443
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001275214.1 → NP_001262143.1  putzig, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP57
      Conserved Domains (4) summary
      sd00017
      Location:360 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:268 → 289
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:373 → 399
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:375 → 443
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP57 Q9VP57

    Gene LinkOut

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