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    Tet Ten-Eleven Translocation (TET) family protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38347, updated on 17-Dec-2024

    Summary

    Official Symbol
    Tetprovided by FlyBase
    Official Full Name
    Ten-Eleven Translocation (TET) family proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263392
    Locus tag
    Dmel_CG43444
    See related
    AllianceGenome:FB:FBgn0263392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2083; CG43444; CG9973; DMAD; Dmel\CG43444; DNA 6mA; dTet; dTET; Idax; TET
    Old locus tag
    Dmel_CG2083; Dmel_CG9973
    Summary
    Enables broad specificity oxidative DNA demethylase activity. Involved in several processes, including DNA modification; germ cell development; and retrotransposon silencing. Located in nucleus. Is expressed in several structures, including antennal anlage; ganglia; germline cell; head epidermis primordium; and larval imaginal tissue. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to several human genes including TET3 (tet methylcytosine dioxygenase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tet in Genome Data Viewer
    Location:
    62F4-63A1; 3-4 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2786207..2879158, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2786207..2879158, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 6 Neighboring gene long non-coding RNA:CR44531 Neighboring gene spatzle 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5-methylcytosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5-methylcytosine dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables broad specificity oxidative DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in RNA modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosomal 5-methylcytosine DNA demethylation pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    Ten-Eleven translocation (TET) family protein
    Names
    CG43444-PA
    CG43444-PB
    CG43444-PC
    CG43444-PD
    CG43444-PE
    CG43444-PF
    DNA 6mA demethylase
    TET family protein
    Tet-PA
    Tet-PB
    Tet-PC
    Tet-PD
    Tet-PE
    Tet-PF
    NP_001246581.1
    NP_001246582.1
    NP_001246583.1
    NP_001261343.1
    NP_001261344.1
    NP_647750.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2786207..2879158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259652.2NP_001246581.1  Ten-Eleven translocation (TET) family protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NDF7, M9NEY8, M9PDW4, M9PEE3, Q8T0I1, Q8T9G4, Q9VZX4
      Conserved Domains (2) summary
      pfam02008
      Location:590630
      zf-CXXC; CXXC zinc finger domain
      pfam12851
      Location:17961929
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    2. NM_001274414.2NP_001261343.1  Ten-Eleven translocation (TET) family protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NEY8
      Conserved Domains (2) summary
      pfam02008
      Location:590630
      zf-CXXC; CXXC zinc finger domain
      pfam12851
      Location:18021935
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    3. NM_001259654.2NP_001246583.1  Ten-Eleven translocation (TET) family protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246583.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NEY8
      Conserved Domains (1) summary
      pfam12851
      Location:9921125
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    4. NM_001259653.1NP_001246582.1  Ten-Eleven translocation (TET) family protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NEY8
      Conserved Domains (2) summary
      pfam02008
      Location:646686
      zf-CXXC; CXXC zinc finger domain
      pfam12851
      Location:18511984
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    5. NM_001274415.1NP_001261344.1  Ten-Eleven translocation (TET) family protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261344.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NEY8
      Conserved Domains (2) summary
      pfam02008
      Location:646686
      zf-CXXC; CXXC zinc finger domain
      pfam12851
      Location:18571990
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    6. NM_139493.4NP_647750.4  Ten-Eleven translocation (TET) family protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647750.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NEY8
      Conserved Domains (1) summary
      pfam12851
      Location:9921125
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily