aru arouser [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aruprovided by FlyBase
Official Full Name: arouserprovided by FlyBase
Primary source: FLYBASE:FBgn0029095
Locus tag: Dmel_CG4276
See related: AllianceGenome:FB:FBgn0029095
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4276; Dmel\CG4276; EPS8L3
Summary: Predicted to enable actin binding activity. Involved in several processes, including memory; olfactory behavior; and response to ethanol. Located in synapse. Is expressed in adult abdomen; adult brain; adult head; adult thorax; and organism. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102 and autosomal recessive nonsyndromic deafness 106. Orthologous to several human genes including EPS8L1 (EPS8 signaling adaptor L1) and EPS8L2 (EPS8 signaling adaptor L2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 21E2-21E2; 2-1.5 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (861849..868354, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (861849..868354, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations of the aru EPS8L3 gene interact with the alleles of a particular genetic background to regulate arouser expression and reveals a role of this gene in memory.
Title: The arouser EPS8L3 gene is critical for normal memory in Drosophila.
This study demonistrated that arouser reveals a role for synapse number in the regulation of ethanol sensitivity in Drosophila melanogaster.
Title: arouser reveals a role for synapse number in the regulation of ethanol sensitivity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in memory	IDA Inferred from Direct Assay more info	PubMed
involved_in olfactory behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synapse structure or activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: arouser

Names: CG4276-PA; CG4276-PC; CG4276-PD; EPS8L3; aru-PA; aru-PC; aru-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

861849..868354 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078725.3 → NP_523449.2 arouser, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523449.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3Z9, Q9VPU7

Related

FBpp0077695

Conserved Domains (2) summary

cd11764
Location:664 → 717

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:55 → 188

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
NM_164395.1 → NP_722665.1 arouser, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722665.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3Z9, Q9VPU7

Related

FBpp0077696, FBtr0078032

Conserved Domains (2) summary

cd11764
Location:664 → 717

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:55 → 188

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
NM_164393.1 → NP_722663.1 arouser, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722663.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMF7, Q8IPW1

Related

FBpp0077697, FBtr0078033

Conserved Domains (2) summary

cd11764
Location:691 → 744

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:82 → 215

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain