Atg1 Autophagy-related 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg1provided by FlyBase
Official Full Name: Autophagy-related 1provided by FlyBase
Primary source: FLYBASE:FBgn0260945
Locus tag: Dmel_CG10967
See related: AllianceGenome:FB:FBgn0260945
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.287; atg; atg-1; atg1; ATG1; CG10967; dAtg1; dATG1; DK-4; DmATG1; Dmel\CG10967; l(3)00305; ULK1; UNC 51-like; unc-51; Unc-51; unc51; Unc51
Summary: Enables protein serine/threonine kinase activity and ubiquitin-like protein binding activity. Involved in several processes, including T-tubule organization; macroautophagy; and programmed cell death involved in cell development. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; ganglia; head; and synaptic neuropil domain. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1) and ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 69E2-69E4; 3-39 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12784429..12805116, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12777529..12798216, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster).
Title: Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster).
Atg1 modulates mitochondrial dynamics to promote germline stem cell maintenance in Drosophila.
Title: Atg1 modulates mitochondrial dynamics to promote germline stem cell maintenance in Drosophila.
Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
Title: Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.
Title: Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.
Atg1-mediated autophagy suppresses tissue degeneration in Pink1/Parkin mutants by promoting mitochondrial fission in Drosophila.
Title: Atg1-mediated autophagy suppresses tissue degeneration in pink1/parkin mutants by promoting mitochondrial fission in Drosophila.
Relish controls autophagy by regulating the expression of Atg1, a core component and activator of the autophagy pathway.
Title: The NF-κB Factor Relish Regulates Atg1 Expression and Controls Autophagy.
dAtg1 has a previously unrecognized function for both regenerative and overgrowth-promoting apoptosis-induced proliferation (AiP) in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP.
Title: Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation.
Data indicate that autophagy-related 1 (Atg1) and ADUK/Ulk3 (CG8866) represent alternative catalytic components of a shared autophagy kinase complex.
Title: Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK.
The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos.
Title: The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos.
Atg17 is required for the kinase activity of endogenous Atg1 in vivo
Title: Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Autophagy-related 1

Names: Atg1-PA; Atg1-PB; Autophagy-specific gene 1; CG10967-PA; CG10967-PB; autophagy-related gene 1; autophagy-specific gene1; pegarn; uncoordinated movement-51

NP_001163433.1

EC 2.7.11.1

NP_648601.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12784429..12805116 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140344.3 → NP_648601.1 Autophagy-related 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648601.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VU14

Related

FBpp0075677

Conserved Domains (3) summary

smart00220
Location:9 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14120
Location:15 → 273

STKc_ULK1_2-like; Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins

pfam12063
Location:618 → 824

DUF3543; Domain of unknown function (DUF3543)
NM_001169962.2 → NP_001163433.1 Autophagy-related 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163433.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQJ7

Conserved Domains (3) summary

smart00220
Location:9 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14120
Location:15 → 273

STKc_ULK1_2-like; Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins

pfam12063
Location:638 → 844

DUF3543; Domain of unknown function (DUF3543)