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    mEFTs mitochondrial translation elongation factor Ts [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35060, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mEFTsprovided by FlyBase
    Official Full Name
    mitochondrial translation elongation factor Tsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032646
    Locus tag
    Dmel_CG6412
    See related
    AllianceGenome:FB:FBgn0032646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6412; Dmel\CG6412; mtEF-Ts
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic large intestine; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mEFTs in Genome Data Viewer
    Location:
    36C10-36C10; 2-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17499268..17501106, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17499268..17501106, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene quail Neighboring gene antisense RNA:CR45715 Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 36C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Paradoxical Mitophagy Regulation by PINK1 and TUFm. Lin J, et al. Mol Cell, 2020 Nov 19. PMID 33113344
    2. Energy biogenesis: one key for coordinating two genomes. Sardiello M, et al. Trends Genet, 2005 Jan. PMID 15680507
    3. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
    4. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
    5. Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis. Olesnicky EC, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347626, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial translation elongation factor Ts
    Names
    CG6412-PA
    mEFTs-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17499268..17501106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136003.5 → NP_609847.1  mitochondrial translation elongation factor Ts [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJC7
      Related
      FBpp0080547
      Conserved Domains (3) summary
      COG0264
      Location:35 → 303
      Tsf; Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]
      cd14275
      Location:32 → 66
      UBA_EF-Ts; UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes
      pfam00889
      Location:98 → 300
      EF_TS; Elongation factor TS
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJC7.1 Q9VJC7

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