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    Mtk Metchnikowin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36708, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Mtkprovided by FlyBase
    Official Full Name
    Metchnikowinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014865
    Locus tag
    Dmel_CG8175
    See related
    AllianceGenome:FB:FBgn0014865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH07954; CG8175; DIM 17; Dmel\CG8175; Mek; Metc; metch; Metch; METCH; metk; mtk
    Summary
    Involved in defense response to other organism and response to wounding. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mtk in Genome Data Viewer
    Location:
    52A1-52A1; 2-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15408846..15409113)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11296351..11296618)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene double parked Neighboring gene SR Protein Kinase Neighboring gene long non-coding RNA:CR45020 Neighboring gene Stac-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens. Rahnamaeian M, et al. J Exp Bot, 2009. PMID 19734262, Free PMC Article
    2. The selective antifungal activity of Drosophila melanogaster metchnikowin reflects the species-dependent inhibition of succinate-coenzyme Q reductase. Moghaddam MB, et al. Sci Rep, 2017 Aug 15. PMID 28811531, Free PMC Article
    3. Effect of allyl-isothiocyanate on survival and antimicrobial peptide expression following oral bacterial infections in Drosophila melanogaster. Zimmermann C, et al. Front Immunol, 2024. PMID 38803500, Free PMC Article
    4. Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects. Woolley VC, et al. J Invertebr Pathol, 2020 Nov. PMID 33022282, Free PMC Article
    5. Larval food quality affects adult (but not larval) immune gene expression independent of effects on general condition. Fellous S, et al. Mol Ecol, 2010 Apr. PMID 20196811

    See all (365) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.
      Title: Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.
    2. activation controlled by Forkhead
      Title: Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila.
    3. DEAF-1 activates the expression of Mtk and Drs promoter.
      Title: DEAF-1 regulates immunity gene expression in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antibacterial humoral response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in antifungal humoral response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antifungal humoral response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in antifungal humoral response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to fungus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium HEP PubMed 
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metchnikowin
    Names
    CG8175-PA
    Mtk-PA
    drosophila immune induced molecule 17
    metchikowin
    metchinkowin
    metchnikovin
    metchnikowin A
    metchnikowin B
    metchnikowin precursor
    metchnikowin-1
    metchnikowin-2
    metchnikowine
    metchnkowin
    takeout

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15408846..15409113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079028.3 → NP_523752.1  metchnikowin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523752.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24395, Q24396, Q86BV8, Q9V7B9
      Related
      FBpp0086518
      Conserved Domains (1) summary
      pfam08105
      Location:1 → 50
      Antimicrobial10; Metchnikowin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24395.1 Q24395

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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