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    ACXD Adenylyl cyclase X D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38284, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ACXDprovided by FlyBase
    Official Full Name
    Adenylyl cyclase X Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040507
    Locus tag
    Dmel_CG5712
    See related
    AllianceGenome:FB:FBgn0040507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC; CG5712; DACXD; Dmel\CG5712
    Summary
    Predicted to enable adenylate cyclase activity. Involved in olfactory behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut; germline cell; and gonad. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ACXD in Genome Data Viewer
    Location:
    62D3-62D3; 3-2 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2237608..2243719)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2237608..2243719)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Outer segment 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Internal-state-dependent modulation of olfactory responses: a tale of dopamine neurons in the adult Drosophila mushroom body. Lin S. Curr Opin Insect Sci, 2023 Oct. PMID 37611806
    2. Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites. Kuhn-Parnell EJ, et al. Genetics, 2008 Jul. PMID 18562648, Free PMC Article
    3. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085
    4. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article
    5. A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Apr. PMID 11180822

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase X D
    Names
    ACXD-PA
    ACXD-PB
    CG5712-PA
    CG5712-PB
    NP_001261320.1
    NP_620469.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2237608..2243719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274391.1 → NP_001261320.1  adenylyl cyclase X D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE08
      Conserved Domains (3) summary
      smart00044
      Location:254 → 476
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam16214
      Location:42 → 284
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:321 → 503
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    2. NM_138984.4 → NP_620469.2  adenylyl cyclase X D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_620469.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGU9, Q9W038
      Related
      FBpp0072753
      Conserved Domains (3) summary
      smart00044
      Location:254 → 476
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam16214
      Location:42 → 284
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:321 → 503
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE08 M9PE08
    Q8IGU9 Q8IGU9
    Q9NJ99 Q9NJ99
    Q9W038 Q9W038

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