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    chk chaski [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chkprovided by FlyBase
    Official Full Name
    chaskiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033095
    Locus tag
    Dmel_CG3409
    See related
    AllianceGenome:FB:FBgn0033095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3409; Chk; Dmel\CG3409
    Summary
    Enables monocarboxylic acid transmembrane transporter activity. Involved in export across plasma membrane and monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; head epidermis primordium; and visceral mesoderm derivative. Orthologous to several human genes including SLC16A14 (solute carrier family 16 member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See chk in Genome Data Viewer
    Location:
    42C5-42C6; 2-55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6699695..6715892, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2587200..2603397, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene MOB kinase activator 4 Neighboring gene Rab2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43611 Neighboring gene mir-4975 stem loop Neighboring gene Zinc/iron regulated transporter-related protein 42C.1 Neighboring gene Zinc/iron regulated transporter-related protein 42C.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal lactate levels depend on glia-derived lactate during high brain activity in Drosophila. González-Gutiérrez A, et al. Glia, 2020 Jun. PMID 31876077
    2. Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress. Delgado MG, et al. Sci Rep, 2018 Jan 19. PMID 29352169, Free PMC Article
    3. A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. Xu D, et al. PLoS Genet, 2023 Sep. PMID 37733679, Free PMC Article
    4. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
    5. A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation. Gándara L, et al. Sci Rep, 2019 Dec 27. PMID 31882718, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monocarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monocarboxylic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monocarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monocarboxylic acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chaski
    Names
    CG3409-PA
    CG3409-PB
    CG3409-PC
    chk-PA
    chk-PB
    chk-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6699695..6715892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169592.2 → NP_001163063.1  chaski, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163063.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T043, Q9V9B3
      Conserved Domains (1) summary
      cd06174
      Location:143 → 315
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_136386.4 → NP_610230.3  chaski, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610230.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T043, Q9V9B3
      Related
      FBpp0085473
      Conserved Domains (1) summary
      cd06174
      Location:143 → 315
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    3. NM_001273804.1 → NP_001260733.1  chaski, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T043, Q9V9B3
      Conserved Domains (1) summary
      cd06174
      Location:143 → 315
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T043 Q8T043

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