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    Sh2b1 SH2B adaptor protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sh2b1provided by RGD
    Official Full Name
    SH2B adaptor protein 1provided by RGD
    Primary source
    RGD:620132
    See related
    EnsemblRapid:ENSRNOG00000049181 AllianceGenome:RGD:620132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sh2b; Sh2-b; Sh2bpsm1
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in intracellular signal transduction; positive regulation of mitotic nuclear division; and regulation of DNA biosynthetic process. Predicted to act upstream of or within cell motility; lamellipodium assembly; and positive regulation of SMAD protein signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Orthologous to human SH2B1 (SH2B adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 65.5), Kidney (RPKM 60.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh2b1 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190479211..190492030, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181048622..181057036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197878839..197888223, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CD19 molecule Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene uncharacterized LOC134483838 Neighboring gene ataxin 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway. Yuan J, et al. Mol Med Rep, 2018 Sep. PMID 30015896, Free PMC Article
    2. The yeast tribrid system--genetic detection of trans-phosphorylated ITAM-SH2-interactions. Osborne MA, et al. Biotechnology (N Y), 1995 Dec. PMID 9636306
    3. New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth. Shih CH, et al. PLoS One, 2013. PMID 24260264, Free PMC Article
    4. Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation. Chen L, et al. Mol Cell Biol, 2004 May. PMID 15082760, Free PMC Article
    5. SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10. Chen L, et al. Mol Endocrinol, 2008 Feb. PMID 17947375, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-14 2-3 p not only mitigate cardiac hypertrophy by directly inhibit the expression of gene SH2B1, but also can protect mitochondrial function in cardiac hypertrophy of vitro and vivo.
      Title: Overexpression of miR-142-3p improves mitochondrial function in cardiac hypertrophy.
    2. SH2B1 overexpression resulted in increased viability, reduced lactate dehydrogenase release and a reduction in the expression levels of proteins associated with the apoptotic cascade in PC12 cells under the oxygenglucose deprivation condition.
      Title: SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway.
    3. These findings suggest that SH2B1-IRSp53 complexes promote the formation of filopodia, neurite initiation, and neuronal branching.
      Title: SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches.
    4. findings demonstrate that SH2B1beta promotes BDNF-induced neurite outgrowth through enhancing pathways involved MEK-ERK1/2 and PI3K-AKT.
      Title: New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth.
    5. Long-Evans rats maintained on chow or a high-fat diet (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats
      Title: Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology.
    6. These findings provide significant new insights into how N-cadherin-mediated inter-cellular interactions may influence neurite initiation and how SH2B1beta may regulate these processes.
      Title: SH2B1β regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation.
    7. SH2B1beta must shuttle between the plasma membrane and nucleus to function as a critical component of NGF-induced gene expression and neuronal differentiation.
      Title: Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes.
    8. SH2B1beta enhances FGF1-induced neurite outgrowth in PC12 cells mainly through MEK-ERK1/2-STAT3-Egr1 pathway.
      Title: SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.
    9. Results suggest that SH2B1beta stimulates NGF-induced neuronal differentiation at least in part by enhancing expression of a specific subset of NGF-sensitive genes, including Plaur, Mmp3, and/or Mmp10, required for neurite outgrowth.
      Title: SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.
    10. SH2-Bbeta and APS do not activate JAK2 as a consequence of their own dimerization, recruitment of an activator of JAK2, or direct competition with a JAK2 inhibitor for binding to JAK2. They most likely induce or stabilize an active conformation of JAK2.
      Title: Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH2B adapter protein 1
    Names
    SH2 domain-containing protein 1B
    SH2-B PH domain-containing signaling mediator 1
    fceRI gamma-chain-interacting protein SH2-B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048180.1 → NP_001041645.1  SH2B adapter protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001041645.1

      Status: VALIDATED

      Source sequence(s)
      AAHX01008496, AF047577, AI029537, BM389529, U57391
      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I967
      Conserved Domains (3) summary
      cd10346
      Location:518 → 614
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:247 → 378
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:26 → 81
      Phe_ZIP; Phenylalanine zipper

    2. NM_134456.3 → NP_604451.2  SH2B adapter protein 1 isoform 1

      See identical proteins and their annotated locations for NP_604451.2

      Status: VALIDATED

      Source sequence(s)
      AF047577, AI029537, BM389529, CB742512, U57391
      UniProtKB/Swiss-Prot
      O55072, Q62985
      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I961
      Conserved Domains (4) summary
      cd10346
      Location:518 → 614
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:247 → 378
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:312 → 376
      PH; PH domain
      pfam08916
      Location:26 → 81
      Phe_ZIP; Phenylalanine zipper

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190479211..190492030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230354.5 → XP_006230416.1  SH2B adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006230416.1

      UniProtKB/Swiss-Prot
      O55072, Q62985
      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I961
      Conserved Domains (4) summary
      cd10346
      Location:518 → 614
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:247 → 378
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:312 → 376
      PH; PH domain
      pfam08916
      Location:26 → 81
      Phe_ZIP; Phenylalanine zipper

    2. XM_063276001.1 → XP_063132071.1  SH2B adapter protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I967

    3. XM_063275992.1 → XP_063132062.1  SH2B adapter protein 1 isoform X2

      UniProtKB/TrEMBL
      A6I963, M0R617

    4. XM_063275999.1 → XP_063132069.1  SH2B adapter protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I970

    5. XM_063275993.1 → XP_063132063.1  SH2B adapter protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I970

    6. XM_063275991.1 → XP_063132061.1  SH2B adapter protein 1 isoform X2

      UniProtKB/TrEMBL
      A6I963, M0R617

    7. XM_039093107.2 → XP_038949035.1  SH2B adapter protein 1 isoform X2

      UniProtKB/TrEMBL
      A6I963, M0R617
      Related
      ENSRNOP00000066048.3, ENSRNOT00000074274.4
      Conserved Domains (3) summary
      cd10346
      Location:518 → 614
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:247 → 378
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:26 → 81
      Phe_ZIP; Phenylalanine zipper

    8. XM_039093117.2 → XP_038949045.1  SH2B adapter protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I970
      Related
      ENSRNOP00000064854.3, ENSRNOT00000071241.5
      Conserved Domains (3) summary
      cd10346
      Location:518 → 614
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:247 → 378
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:26 → 81
      Phe_ZIP; Phenylalanine zipper

    9. XM_006230353.5 → XP_006230415.1  SH2B adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006230415.1

      UniProtKB/Swiss-Prot
      O55072, Q62985
      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I961
      Conserved Domains (4) summary
      cd10346
      Location:518 → 614
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:247 → 378
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:312 → 376
      PH; PH domain
      pfam08916
      Location:26 → 81
      Phe_ZIP; Phenylalanine zipper

    10. XM_063276000.1 → XP_063132070.1  SH2B adapter protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I967

    11. XM_039093126.2 → XP_038949054.1  SH2B adapter protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QYJ5, A6I967
      Conserved Domains (3) summary
      cd10346
      Location:518 → 614
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:247 → 378
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:26 → 81
      Phe_ZIP; Phenylalanine zipper

    RNA

    1. XR_005493701.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62985.1 GenPept UniProtKB/Swiss-Prot:Q62985

    Gene LinkOut

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