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    Amer2 APC membrane recruitment 2 [ Mus musculus (house mouse) ]

    Gene ID: 72125, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Amer2provided by MGI
    Official Full Name
    APC membrane recruitment 2provided by MGI
    Primary source
    MGI:MGI:1919375
    See related
    Ensembl:ENSMUSG00000021986 AllianceGenome:MGI:1919375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam123a; 2600011E07Rik
    Summary
    Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in ectoderm development and negative regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human AMER2 (APC membrane recruitment protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 8.0), whole brain E14.5 (RPKM 7.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Amer2 in Genome Data Viewer
    Location:
    14 D1; 14 31.62 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60615141..60625642)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60373288..60388197)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60870359-60870542 Neighboring gene nucleoporin 58 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60883833-60884016 Neighboring gene myotubularin related protein 6 Neighboring gene STARR-seq mESC enhancer starr_36856 Neighboring gene STARR-seq mESC enhancer starr_36857 Neighboring gene predicted gene, 34874 Neighboring gene peptidylprolyl isomerase A pseudogene 14_696.1 Neighboring gene spermatogenesis associated 13 Neighboring gene STARR-positive B cell enhancer ABC_E11785 Neighboring gene VISTA enhancer mm1122 Neighboring gene predicted gene, 41166

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression patterns of the Wtx/Amer gene family during mouse embryonic development. Comai G, et al. Dev Dyn, 2010 Jun. PMID 20503382
    2. Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. Pfister AS, et al. J Biol Chem, 2012 Oct 12. PMID 22898821, Free PMC Article
    3. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
    4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
      Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ectoderm development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    APC membrane recruitment protein 2
    Names
    family with sequence similarity 123, member A
    protein FAM123A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164705.2 → NP_001158177.2  APC membrane recruitment protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166113
      Consensus CDS
      CCDS88682.1
      UniProtKB/TrEMBL
      A0A0R4J030
      Related
      ENSMUSP00000153031.3, ENSMUST00000225247.3
      Conserved Domains (1) summary
      pfam09422
      Location:94 → 463
      WTX; WTX protein

    2. NM_001368677.1 → NP_001355606.1  APC membrane recruitment protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166113
      UniProtKB/TrEMBL
      A0A0R4J030
      Conserved Domains (1) summary
      pfam09422
      Location:94 → 532
      WTX; WTX protein

    3. NM_028113.4 → NP_082389.2  APC membrane recruitment protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166113
      Consensus CDS
      CCDS27177.2
      UniProtKB/Swiss-Prot
      Q7TNC5, Q8CCJ4, Q8K0U9, Q9D0Q2
      UniProtKB/TrEMBL
      A0A0R4J030
      Related
      ENSMUSP00000022561.8, ENSMUST00000022561.9
      Conserved Domains (1) summary
      pfam09422
      Location:94 → 589
      WTX; WTX protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      60615141..60625642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCJ4.2 GenPept UniProtKB/Swiss-Prot:Q8CCJ4

    Gene LinkOut

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