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    Chac2 ChaC, cation transport regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 68044, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chac2provided by MGI
    Official Full Name
    ChaC, cation transport regulator 2provided by MGI
    Primary source
    MGI:MGI:1915294
    See related
    Ensembl:ENSMUSG00000020309 AllianceGenome:MGI:1915294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 15.9), liver E14.5 (RPKM 12.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chac2 in Genome Data Viewer
    Location:
    11 A4; 11 18.2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30926707..30936365, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30976707..30986365, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene G protein-coupled receptor 75 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene GPN-loop GTPase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29073 Neighboring gene STARR-seq mESC enhancer starr_29074 Neighboring gene STARR-seq mESC enhancer starr_29075 Neighboring gene STARR-seq mESC enhancer starr_29076 Neighboring gene predicted gene, 40822

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. Kaur A, et al. J Biol Chem, 2017 Jan 13. PMID 27913623, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • 2510006C20Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione specific gamma-glutamylcyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative glutathione-specific gamma-glutamylcyclotransferase 2
    Names
    ChaC, cation transport regulator homolog 2
    cation transport regulator-like protein 2
    gamma-GCG 2
    NP_001277596.1
    NP_080803.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290667.1 → NP_001277596.1  putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2

      See identical proteins and their annotated locations for NP_001277596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK010914, AK021391, AL662891, BY333527
      Consensus CDS
      CCDS70154.1
      UniProtKB/Swiss-Prot
      Q9CQG1
      Related
      ENSMUSP00000020553.5, ENSMUST00000020553.5
      Conserved Domains (1) summary
      pfam04752
      Location:1 → 162
      ChaC; ChaC-like protein

    2. NM_026527.3 → NP_080803.1  putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_080803.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK078993, AL662891, BY333527
      Consensus CDS
      CCDS24510.1
      UniProtKB/Swiss-Prot
      Q8R3K5, Q9CQG1, Q9D1T7
      Related
      ENSMUSP00000098942.5, ENSMUST00000101394.5
      Conserved Domains (1) summary
      pfam04752
      Location:1 → 174
      ChaC; ChaC-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      30926707..30936365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQG1.1 GenPept UniProtKB/Swiss-Prot:Q9CQG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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