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    CYP76C4 cytochrome P450, family 76, subfamily C, polypeptide 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819163, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP76C4
    Official Full Name
    cytochrome P450, family 76, subfamily C, polypeptide 4
    Primary source
    TAIR:AT2G45550
    Locus tag
    AT2G45550
    See related
    Araport:AT2G45550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; F17K2.8; family 76; polypeptide 4; polypeptide 4''; subfamily C
    Summary
    member of CYP76C
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    Genomic context

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    See CYP76C4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (18773517..18775797, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene WD-40 repeat family protein / beige-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytochrome P450, family 76, subfamily C, polypeptide 1 Neighboring gene cytochrome P450, family 76, subfamily C, polypeptide 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway. Höfer R, et al. Metab Eng, 2013 Nov. PMID 23933465
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYP76B6 emerged as a highly specialized multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol
      Title: Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 8-hydroxygeraniol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 76, subfamily C, polypeptide 4
    NP_182079.1
    • ''cytochrome P450, family 76, subfamily C, polypeptide 4'' (CYP76C4); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: oxidation reduction; EXPRESSED IN: stem, root, carpel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 76, subfamily C, polypeptide 1 (TAIR:AT2G45560.1); Has 35109 Blast hits to 34843 proteins in 1784 species: Archae - 57; Bacteria - 4750; Metazoa - 11986; Fungi - 7467; Plants - 9491; Viruses - 6; Other Eukaryotes - 1352 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18773517..18775797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130117.2 → NP_182079.1  cytochrome P450, family 76, subfamily C, polypeptide 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64635
      UniProtKB/TrEMBL
      A0A178VUL7
      Conserved Domains (1) summary
      cd11073
      Location:66 → 504
      CYP76-like; cytochrome P450 family 76 and similar cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64635.1

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