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    FUS5 Proteasome component (PCI) domain protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839241, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FUS5
    Official Full Name
    Proteasome component (PCI) domain protein
    Primary source
    TAIR:AT1G02090
    Locus tag
    AT1G02090
    See related
    Araport:AT1G02090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA COP9 SIGNALOSOME SUBUNIT 7; ATCSN7; CONSTITUTIVE PHOTOMORPHOGENIC 15; COP15; COP9 SIGNALOSOME SUBUNIT 7; CSN7; FUSCA 5; T7I23.25; T7I23_25
    Summary
    encodes a phosphoprotein that is a subunit of the COP9 signalosome. Mutants exhibit constitutive photomorphogenic phenotype.
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    Genomic context

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    See FUS5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (387277..389808, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene zinc ion-binding protein Neighboring gene transcription regulator Neighboring gene Leucine carboxyl methyltransferase Neighboring gene bZIP domain class transcription factor (DUF630 and DUF632)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis FUSCA5 encodes a novel phosphoprotein that is a component of the COP9 complex. Karniol B, et al. Plant Cell, 1999 May. PMID 10330469, Free PMC Article
    2. The Arabidopsis COP9 signalosome subunit 7 is a model PCI domain protein with subdomains involved in COP9 signalosome assembly. Dessau M, et al. Plant Cell, 2008 Oct. PMID 18854373, Free PMC Article
    3. Crystal structure and versatile functional roles of the COP9 signalosome subunit 1. Lee JH, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818606, Free PMC Article
    4. CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome. Wang X, et al. Mol Biol Cell, 2002 Feb. PMID 11854419, Free PMC Article
    5. Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Serino G, et al. Plant Cell, 1999 Oct. PMID 10521526, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CSN is a negative regulator of RNR activity in Arabidopsis.
      Title: COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2).
    2. CSN7 contains a PCI motif and is involved in COP9 signalosome assembly.
      Title: The Arabidopsis COP9 signalosome subunit 7 is a model PCI domain protein with subdomains involved in COP9 signalosome assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100089.3
    NM_179245.3
    NM_202010.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within COP9 signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Proteasome component (PCI) domain protein
    NP_563645.1
    • FUSCA 5 (FUS5); CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717); Has 689 Blast hits to 689 proteins in 163 species: Archae - 0; Bacteria - 0; Metazoa - 405; Fungi - 166; Plants - 80; Viruses - 0; Other Eukaryotes - 38 (source: NCBI BLink).
    NP_849576.1
    • FUSCA 5 (FUS5); CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717); Has 683 Blast hits to 683 proteins in 162 species: Archae - 0; Bacteria - 0; Metazoa - 406; Fungi - 161; Plants - 78; Viruses - 0; Other Eukaryotes - 38 (source: NCBI BLink).
    NP_973739.1
    • FUSCA 5 (FUS5); CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      387277..389808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100089.3 → NP_563645.1  Proteasome component (PCI) domain protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81247, Q94JU3
      UniProtKB/TrEMBL
      A0A178W722, A0A5S9S6P8
      Conserved Domains (1) summary
      smart00088
      Location:86 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    2. NM_179245.3 → NP_849576.1  Proteasome component (PCI) domain protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849576.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9S6P8
      Conserved Domains (1) summary
      smart00088
      Location:86 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    3. NM_202010.3 → NP_973739.1  Proteasome component (PCI) domain protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973739.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6J6, A0A5S9S6P8, F4HVW0
      Conserved Domains (1) summary
      smart00088
      Location:86 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94JU3.1

    Gene LinkOut

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