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    Bifunctional dihydrofolate reductase/thymidylate synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816694, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Bifunctional dihydrofolate reductase/thymidylate synthase
    Primary source
    TAIR:AT2G21550
    Locus tag
    AT2G21550
    See related
    Araport:AT2G21550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2G1.18; F2G1_18
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (9226917..9230205)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene SMAD/FHA domain-containing protein Neighboring gene SEC14-like 3 Neighboring gene nucleolar-like protein Neighboring gene tRNA-Tyr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants. Gorelova V, et al. Plant Cell, 2017 Nov. PMID 28939595, Free PMC Article
    2. Distinctive features and differential regulation of the DRTS genes of Arabidopsis thaliana. Maniga A, et al. PLoS One, 2017. PMID 28594957, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Bifunctional dihydrofolate reductase/thymidylate synthase
    NP_179750.1
    • Bifunctional dihydrofolate reductase/thymidylate synthase; FUNCTIONS IN: thymidylate synthase activity, dihydrofolate reductase activity; INVOLVED IN: oxidation reduction, glycine biosynthetic process, one-carbon metabolic process, nucleotide biosynthetic process, dTMP biosynthetic process; EXPRESSED IN: stem, hypocotyl, root; CONTAINS InterPro DOMAIN/s: Dihydrofolate reductase domain (InterPro:IPR001796), Dihydrofolate reductase conserved site (InterPro:IPR017925), Bifunctional dihydrofolate reductase/thymidylate synthase (InterPro:IPR012262), Thymidylate synthase (InterPro:IPR000398); BEST Arabidopsis thaliana protein match is: thymidylate synthase 1 (TAIR:AT2G16370.1); Has 12633 Blast hits to 12576 proteins in 2517 species: Archae - 33; Bacteria - 8296; Metazoa - 499; Fungi - 419; Plants - 87; Viruses - 227; Other Eukaryotes - 3072 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9226917..9230205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335764.1 → NP_001324557.1  Bifunctional dihydrofolate reductase/thymidylate synthase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B0G7, A0A654EUY5

    2. NM_127727.1 → NP_179750.1  Bifunctional dihydrofolate reductase/thymidylate synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EUY5, Q9SIK4
      Conserved Domains (1) summary
      PTZ00164
      Location:22 → 489
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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