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    G-TMT gamma-tocopherol methyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    G-TMT
    Official Full Name
    gamma-tocopherol methyltransferase
    Primary source
    TAIR:AT1G64970
    Locus tag
    AT1G64970
    See related
    Araport:AT1G64970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F13O11.27; F13O11_27; gamma-tocopherol methyltransferase; GAMMA-TOCOPHEROL METHYLTRANSFERASE; TMT1; VITAMIN E DEFICIENT 4; VTE4
    Summary
    gamma-tocopherol methyltransferase (g-TMT) mRNA, nuclear; mutant has Deficient in alpha and beta tocopherol; Accumulates gamma tocopherol in leaves
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    Genomic context

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    See G-TMT in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (24134085..24136109, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 87, subfamily A, polypeptide 6 Neighboring gene cytochrome P450, family 89, subfamily A, polypeptide 5 Neighboring gene ARM repeat superfamily protein Neighboring gene ncRNA Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene GPCR-type G protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of γ-tocopherol methyltransferase in chloroplasts results in massive proliferation of the inner envelope membrane and decreases susceptibility to salt and metal-induced oxidative stresses by reducing reactive oxygen species. Jin S, et al. Plant Biotechnol J, 2014 Dec. PMID 25051898, Free PMC Article
    2. Accumulation of γ- rather than α-tocopherol alters ethylene signaling gene expression in the vte4 mutant of Arabidopsis thaliana. Cela J, et al. Plant Cell Physiol, 2011 Aug. PMID 21719428, Free PMC Article
    3. Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana. Koch M, et al. Eur J Biochem, 2003 Jan. PMID 12492478
    4. Elevating the vitamin E content of plants through metabolic engineering. Shintani D, et al. Science, 1998 Dec 11. PMID 9851934
    5. Inactivation of genes, encoding tocopherol biosynthetic pathway enzymes, results in oxidative stress in outdoor grown Arabidopsis thaliana. Semchuk NM, et al. Plant Physiol Biochem, 2009 May. PMID 19264498

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of gamma-TMT in regulating abiotic stress within chloroplasts, was investigated.
      Title: Expression of γ-tocopherol methyltransferase in chloroplasts results in massive proliferation of the inner envelope membrane and decreases susceptibility to salt and metal-induced oxidative stresses by reducing reactive oxygen species.
    2. Jasmonic acid and ethylene signaling pathways are down-regulated in mature leaves of salt-stressed vte4 plants.
      Title: Accumulation of γ- rather than α-tocopherol alters ethylene signaling gene expression in the vte4 mutant of Arabidopsis thaliana.
    3. Results show that both vte1 and vte4 mutant plant lines had higher concentration of protein carbonyl groups and oxidized glutathione compared to the wild type, indicating the development of oxidative stress.
      Title: Inactivation of genes, encoding tocopherol biosynthetic pathway enzymes, results in oxidative stress in outdoor grown Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_105171.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tocopherol C-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in vitamin E biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vitamin E biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    gamma-tocopherol methyltransferase
    NP_176677.1
    • gamma-tocopherol methyltransferase (G-TMT); CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (TAIR:AT1G73600.1); Has 14618 Blast hits to 14609 proteins in 2288 species: Archae - 408; Bacteria - 10917; Metazoa - 203; Fungi - 466; Plants - 497; Viruses - 0; Other Eukaryotes - 2127 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24134085..24136109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105171.3 → NP_176677.1  gamma-tocopherol methyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XIP9, Q9ZSK1
      UniProtKB/TrEMBL
      A0A5S9WPE5, A0A654EL26
      Conserved Domains (1) summary
      PLN02244
      Location:3 → 348
      PLN02244; tocopherol O-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZSK1.2

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