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    D-CDES D-cysteine desulfhydrase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841263, updated on 18-Sep-2024

    Summary

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    Official Symbol
    D-CDES
    Official Full Name
    D-cysteine desulfhydrase
    Primary source
    TAIR:AT1G48420
    Locus tag
    AT1G48420
    See related
    Araport:AT1G48420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DEAMINASE 1; A. THALIANA 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DEAMINASE 1; ACD1; ATACD1; AtDCD; D-cysteine desulfhydrase; DCD; T1N15.3; T1N15_3
    Summary
    Encodes an enzyme that decomposes D-cysteine into pyruvate, H2S, and NH3. Only D-cysteine but not L-cysteine was converted by D-CDes to pyruvate, H2S, and NH3. There is conflicting evidence on its 1-aminocyclopropane-1-carboxylate deaminase activity. Involved in regulating ethylene levels.
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    Genomic context

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    See D-CDES in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (17895784..17898813, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene Stabilizer of iron transporter SufD / Polynucleotidyl transferase Neighboring gene miscRNA Neighboring gene Dihydroxyacetone kinase Neighboring gene B-cell receptor-associated 31-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ethylene levels are regulated by a plant encoded 1-aminocyclopropane-1-carboxylic acid deaminase. McDonnell L, et al. Physiol Plant, 2009 May. PMID 19508369
    2. Isolation and characterization of a D-cysteine desulfhydrase protein from Arabidopsis thaliana. Riemenschneider A, et al. FEBS J, 2005 Mar. PMID 15720402
    3. WRKY13 Enhances Cadmium Tolerance by Promoting D-CYSTEINE DESULFHYDRASE and Hydrogen Sulfide Production. Zhang Q, et al. Plant Physiol, 2020 May. PMID 32179630, Free PMC Article
    4. Cadmium toxicity is alleviated by AtLCD and AtDCD in Escherichia coli. Shen JJ, et al. J Appl Microbiol, 2012 Nov. PMID 22816429
    5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtACD1 can act as a regulator of ACC levels which also regulates ethylene levels.
      Title: Ethylene levels are regulated by a plant encoded 1-aminocyclopropane-1-carboxylic acid deaminase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333334.1
    NM_001333335.1
    NM_103738.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables 1-aminocyclopropane-1-carboxylate deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-aminocyclopropane-1-carboxylate deaminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables D-cysteine desulfhydrase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalt ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-cysteine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stress response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    D-cysteine desulfhydrase
    NP_001319174.1
    • D-cysteine desulfhydrase (D-CDES); FUNCTIONS IN: 1-aminocyclopropane-1-carboxylate deaminase activity, D-cysteine desulfhydrase activity, cobalt ion binding, catalytic activity; INVOLVED IN: response to cadmium ion, ethylene biosynthetic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Pyridoxal phosphate-dependent deaminase (InterPro:IPR005966); BEST Arabidopsis thaliana protein match is: Pyridoxal-5'-phosphate-dependent enzyme family protein (TAIR:AT3G26115.1); Has 2814 Blast hits to 2813 proteins in 938 species: Archae - 31; Bacteria - 1992; Metazoa - 30; Fungi - 102; Plants - 101; Viruses - 0; Other Eukaryotes - 558 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17895784..17898813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333334.1 → NP_001319174.1  D-cysteine desulfhydrase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HYF3, Q8W4C7, Q9SX74
      UniProtKB/TrEMBL
      A0A178WEZ8, A0A5S9WN08
      Conserved Domains (1) summary
      TIGR01275
      Location:54 → 375
      ACC_deam_rel; pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family

    2. NM_001333335.1 → NP_001320840.1  D-cysteine desulfhydrase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HYF3, Q8W4C7, Q9SX74
      UniProtKB/TrEMBL
      A0A178WEZ8, A0A5S9WN08
      Conserved Domains (1) summary
      TIGR01275
      Location:54 → 375
      ACC_deam_rel; pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family

    3. NM_103738.7 → NP_175275.3  D-cysteine desulfhydrase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175275.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HYF3, Q8W4C7, Q9SX74
      UniProtKB/TrEMBL
      A0A178WEZ8, A0A5S9WN08
      Conserved Domains (1) summary
      TIGR01275
      Location:54 → 375
      ACC_deam_rel; pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HYF3.1

    Gene LinkOut

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