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    SUS2 Pre-mRNA-processing-splicing factor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844347, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUS2
    Official Full Name
    Pre-mRNA-processing-splicing factor
    Primary source
    TAIR:AT1G80070
    Locus tag
    AT1G80070
    See related
    Araport:AT1G80070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABNORMAL SUSPENSOR 2; EMB14; EMB177; EMB33; EMBRYO DEFECTIVE 14; EMBRYO DEFECTIVE 177; EMBRYO DEFECTIVE 33; F18B13.15; F18B13_15; PRP8
    Summary
    a genetic locus involved in embryogenesis. Mutations in this locus result in an abnormal suspensor and embryo lethality.
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    Genomic context

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    See SUS2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Sequence:
    Chromosome: 1; NC_003070.9 (30117847..30127811)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene adenine phosphoribosyl transferase 2 Neighboring gene Ubiquitin-like superfamily protein Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene Cystathionine beta-synthase (CBS) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Missplicing suppressor alleles of Arabidopsis PRE-MRNA PROCESSING FACTOR 8 increase splicing fidelity by reducing the use of novel splice sites. Cabezas-Fuster A, et al. Nucleic Acids Res, 2022 Jun 10. PMID 35639749, Free PMC Article
    2. An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs. Llinas RJ, et al. Plant Physiol, 2022 Aug 1. PMID 35608297, Free PMC Article
    3. PRP8A and PRP8B spliceosome subunits act coordinately to control pollen tube attraction in Arabidopsis thaliana. Kulichová K, et al. Development, 2020 Jun 14. PMID 32345744
    4. An Rtf2 Domain-Containing Protein Influences Pre-mRNA Splicing and Is Essential for Embryonic Development in Arabidopsis thaliana. Sasaki T, et al. Genetics, 2015 Jun. PMID 25819795, Free PMC Article
    5. Functional consequences of splicing of the antisense transcript COOLAIR on FLC transcription. Marquardt S, et al. Mol Cell, 2014 Apr 10. PMID 24725596, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs.
      Title: An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs.
    2. Missplicing suppressor alleles of Arabidopsis PRE-MRNA PROCESSING FACTOR 8 increase splicing fidelity by reducing the use of novel splice sites.
      Title: Missplicing suppressor alleles of Arabidopsis PRE-MRNA PROCESSING FACTOR 8 increase splicing fidelity by reducing the use of novel splice sites.
    3. PRP8A and PRP8B spliceosome subunits act coordinately to control pollen tube attraction in Arabidopsis thaliana.
      Title: PRP8A and PRP8B spliceosome subunits act coordinately to control pollen tube attraction in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106656.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables U5 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Pre-mRNA-processing-splicing factor
    NP_178124.2
    • ABNORMAL SUSPENSOR 2 (SUS2); INVOLVED IN: nuclear mRNA splicing, via spliceosome; LOCATED IN: chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mov34/MPN/PAD-1 (InterPro:IPR000555), Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding (InterPro:IPR019581), Pre-mRNA-processing-splicing factor 8 (InterPro:IPR012591), PROCN (InterPro:IPR012592), Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding (InterPro:IPR019580), PRP8 domain IV core (InterPro:IPR021983), PRO, C-terminal (InterPro:IPR012984), RNA recognition motif, spliceosomal PrP8 (InterPro:IPR019582); BEST Arabidopsis thaliana protein match is: Pre-mRNA-processing-splicing factor (TAIR:AT4G38780.1); Has 828 Blast hits to 729 proteins in 312 species: Archae - 0; Bacteria - 2; Metazoa - 333; Fungi - 220; Plants - 69; Viruses - 2; Other Eukaryotes - 202 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30117847..30127811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106656.4 → NP_178124.2  Pre-mRNA-processing-splicing factor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178124.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SSD2
      UniProtKB/TrEMBL
      A0A178W7J7, A0A5S9WVY3, A0A654EQI9
      Conserved Domains (1) summary
      COG5178
      Location:67 → 2359
      PRP8; U5 snRNP spliceosome subunit [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SSD2.1

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