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    ZIP4 zinc transporter [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837640, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZIP4
    Official Full Name
    zinc transporter
    Primary source
    TAIR:AT1G10970
    Locus tag
    AT1G10970
    See related
    Araport:AT1G10970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATZIP4; T19D16.11; T19D16_11; zinc transporter 4 precursor
    Summary
    A member of Zrt- and Irt-related protein (ZIP) family. transcript is induced in response to zinc deficiency in the root and shoot. Expression is regulated by copper, but response to copper deficiency is detected only after three weeks of deficiency.
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    Genomic context

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    See ZIP4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (3665087..3667139, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DNA helicase (RECQl4A) Neighboring gene Protein kinase superfamily protein Neighboring gene transmembrane nine 1 Neighboring gene ferredoxin 1 Neighboring gene Lung seven transmembrane receptor family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens. Xu C, et al. Curr Mol Med, 2014 Mar. PMID 24345208, Free PMC Article
    2. Homologous chromosome pairing is completed in crossover defective atzip4 mutant. Kuromori T, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18348867
    3. Arabidopsis thaliana transcription factors bZIP19 and bZIP23 regulate the adaptation to zinc deficiency. Assunção AG, et al. Proc Natl Acad Sci U S A, 2010 Jun 1. PMID 20479230, Free PMC Article
    4. Zip4/Spo22 is required for class I CO formation but not for synapsis completion in Arabidopsis thaliana. Chelysheva L, et al. PLoS Genet, 2007 May 25. PMID 17530928, Free PMC Article
    5. Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis. Wintz H, et al. J Biol Chem, 2003 Nov 28. PMID 13129917

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens
      Title: ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens.
    2. AtZIP4 plays an important role in normal crossover formation and meiotic chromosome segregation, but not in homolog search.
      Title: Homologous chromosome pairing is completed in crossover defective atzip4 mutant.
    3. These results reveal that Zip4 function in class I crossovers formation is conserved from budding yeast to Arabidopsis.
      Title: Zip4/Spo22 is required for class I CO formation but not for synapsis completion in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001331945.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc transporter
    NP_001318977.1
    • zinc transporter 4 precursor (ZIP4); CONTAINS InterPro DOMAIN/s: Zinc/iron permease, fungal/plant (InterPro:IPR004698), Zinc/iron permease (InterPro:IPR003689); BEST Arabidopsis thaliana protein match is: iron regulated transporter 3 (TAIR:AT1G60960.1); Has 2241 Blast hits to 2085 proteins in 351 species: Archae - 0; Bacteria - 278; Metazoa - 580; Fungi - 588; Plants - 521; Viruses - 0; Other Eukaryotes - 274 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3665087..3667139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331946.1 → NP_001320672.1  zinc transporter [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I7B9, O04089, Q56XS7
      UniProtKB/TrEMBL
      A0A178WA23, A0A5S9TQN2, A0A654EJH3
      Conserved Domains (1) summary
      TIGR00820
      Location:10 → 374
      zip; ZIP zinc/iron transport family

    2. NM_001331945.1 → NP_001318977.1  zinc transporter [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I7B9, O04089, Q56XS7
      UniProtKB/TrEMBL
      A0A178WA23, A0A5S9TQN2, A0A654EJH3
      Conserved Domains (1) summary
      TIGR00820
      Location:10 → 374
      zip; ZIP zinc/iron transport family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04089.1

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