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    RR1 response regulator 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820940, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RR1
    Official Full Name
    response regulator 1
    Primary source
    TAIR:AT3G16857
    Locus tag
    AT3G16857
    See related
    Araport:AT3G16857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARR1; response regulator 1
    Summary
    Encodes an Arabidopsis response regulator (ARR) protein that acts in concert with other type-B ARRs in the cytokinin signaling pathway. Also involved in cytokinin-dependent inhibition of hypocotyl elongation and cytokinin-dependent greening and shooting in tissue culture.
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    Genomic context

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    See RR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (5755714..5759443)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene ncRNA Neighboring gene COBRA-like protein 8 precursor Neighboring gene GATA transcription factor 17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transcriptional repressor ARR1-SRDX suppresses pleiotropic cytokinin activities in Arabidopsis. Heyl A, et al. Plant Physiol, 2008 Jul. PMID 18502977, Free PMC Article
    2. ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions. Taniguchi M, et al. Plant Cell Physiol, 2007 Feb. PMID 17202182
    3. Cytokinin signaling stabilizes the response activator ARR1. Kurepa J, et al. Plant J, 2014 Apr. PMID 24617630
    4. Low temperature inhibits root growth by reducing auxin accumulation via ARR1/12. Zhu J, et al. Plant Cell Physiol, 2015 Apr. PMID 25552473
    5. A genetic framework for the control of cell division and differentiation in the root meristem. Dello Ioio R, et al. Science, 2008 Nov 28. PMID 19039136

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.
      Title: The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.
    2. Authors revealed a new link between auxin and cytokinin signaling involving the interaction between ARR1 and IAA17. ARR1 binds to the IAA17 promoter and promotes its expression, especially at SIM incubation stage, which indirectly represses the expression of WUS and inhibits shoot regeneration.
      Title: The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.
    3. ARR1 role in shoot branching.
      Title: Cytokinin Targets Auxin Transport to Promote Shoot Branching.
    4. The expression signals of AG were detected in the initiating carpel primordia and regenerating carpels, and co-localized with those of two Type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs), ARR1 and ARR10.
      Title: Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis.
    5. Data suggest that shoot removal induces the quantitative and qualitative development of chloroplasts in roots, with cytokinin signaling via RESPONSE REGULATOR (ARR)-ARR1 and ARR12 functioning downstream of wounding signaling to up-regulate genes associated with chloroplast development.
      Title: Shoot Removal Induces Chloroplast Development in Roots via Cytokinin Signaling.
    6. SCR mediates ARR1 transcriptional suppression via the RGA protein.
      Title: A SCARECROW-based regulatory circuit controls Arabidopsis thaliana meristem size from the root endodermis.
    7. The cytokinin module ARABIDOPSIS HISTIDINE KINASE3 (AHK3)/ARABIDOPSIS RESPONSE REGULATOR1 (ARR1)/ARR12 was found to interact with the GR24-dependent reduction in LR development, because mutants in this pathway rendered LR development insensitive to GR24.
      Title: Strigolactones spatially influence lateral root development through the cytokinin signaling network.
    8. An arr1,10,12 triple mutant had more drought tolerance due to enhanced cell membrane integrity, anthocyanin synthesis, abscissic acid hypersensitivity, and reduced stomatal aperture. Dehydration and ABA repressed all 3 genes. RR1 is the most critical.
      Title: Arabidopsis type B cytokinin response regulators ARR1, ARR10, and ARR12 negatively regulate plant responses to drought.
    9. low temperature inhibits root growth by reducing auxin accumulation via ARR1/12.
      Title: Low temperature inhibits root growth by reducing auxin accumulation via ARR1/12.
    10. Cytokinin signaling increases the abundance of ARR1, a ubiquitously expressed type-B response regulators (RRB), by preventing its degradation by the 26S proteasome.
      Title: Cytokinin signaling stabilizes the response activator ARR1.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338265.1
    NM_112561.5
    NM_180269.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphorelay response regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axillary shoot meristem initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within callus formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to cytokinin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of shoot apical meristem identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within primary root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of anthocyanin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of chlorophyll biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cytokinin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of root meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of root meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    response regulator 1
    NP_566561.2
    • response regulator 1 (RR1); CONTAINS InterPro DOMAIN/s: Response regulator, plant B-type (InterPro:IPR017053), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447), CheY-like (InterPro:IPR011006), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: response regulator 2 (TAIR:AT4G16110.1); Has 98862 Blast hits to 97820 proteins in 3027 species: Archae - 653; Bacteria - 87858; Metazoa - 53; Fungi - 404; Plants - 2787; Viruses - 5; Other Eukaryotes - 7102 (source: NCBI BLink).
    NP_850600.2
    • response regulator 1 (RR1); CONTAINS InterPro DOMAIN/s: Response regulator, plant B-type (InterPro:IPR017053), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447), CheY-like (InterPro:IPR011006), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Signal transduction response regulator, receiver domain (InterPro:IPR001789), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: response regulator 2 (TAIR:AT4G16110.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5755714..5759443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180269.3 → NP_850600.2  response regulator 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850600.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VKJ9, A0A7G2ELB6
      Conserved Domains (2) summary
      TIGR01557
      Location:237 → 290
      myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class
      cd17584
      Location:39 → 153
      REC_typeB_ARR-like; phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains

    2. NM_112561.5 → NP_566561.2  response regulator 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566561.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS4, Q940D0, Q9LIB7, Q9ZWK0
      UniProtKB/TrEMBL
      A0A654F7X2, A0A7G2ELB6, Q67YH9
      Conserved Domains (2) summary
      TIGR01557
      Location:237 → 290
      myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class
      cd17584
      Location:39 → 153
      REC_typeB_ARR-like; phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains

    3. NM_001338265.1 → NP_001325499.1  response regulator 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLF2, A0A7G2ELB6
      Conserved Domains (2) summary
      TIGR01557
      Location:167 → 220
      myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class
      cd17584
      Location:1 → 83
      REC_typeB_ARR-like; phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940D0.2

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