SAR1 SUPPRESSOR OF AUXIN RESISTANCE1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SAR1
Official Full Name: SUPPRESSOR OF AUXIN RESISTANCE1
Primary source: TAIR:AT1G33410
Locus tag: AT1G33410
See related: Araport:AT1G33410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS NUCLEOPORIN 160; ATNUP160; F10C21.8; F10C21_8; NUCLEOPORIN 160; NUP160; SUPPRESSOR OF AUXIN RESISTANCE1
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Genomic context

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See SAR1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 26

Sequence:: Chromosome: 1; NC_003070.9 (12109561..12118861, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nucleoporin NUP160 and NUP96 regulate nucleocytoplasmic export of mRNAs and participate in ethylene signaling and response in Arabidopsis.
Title: The nucleoporin NUP160 and NUP96 regulate nucleocytoplasmic export of mRNAs and participate in ethylene signaling and response in Arabidopsis.
The sar1-7 mutant partially restored auxin responsiveness to roots of an rce1 loss-of-function mutant, indicating that AtNUP160/SAR1 is required for proper expression of factors responsible for the repression of auxin signalling.
Title: A loss-of-function mutation in the nucleoporin AtNUP160 indicates that normal auxin signalling is required for a proper ethylene response in Arabidopsis.
The impact of mutations in Nup160, Seh1 and a third complex member, MOS3/Nup96, on EDS1 protein accumulation in the snc1 auto-immune mutant background, was investigated.
Title: Nucleoporins Nup160 and Seh1 are required for disease resistance in Arabidopsis.
The nup160 and seh1 mutants are impaired in nuclear mRNA export.
Title: Putative members of the Arabidopsis Nup107-160 nuclear pore sub-complex contribute to pathogen defense.
Results demonstrate the important role of the plant nuclear pore complex and the nucleoporins SUPPRESSOR OF AUXIN RESISTANCE SAR1 and SAR3 in hormone signaling and development. [SAR1]
Title: The Arabidopsis SUPPRESSOR OF AUXIN RESISTANCE proteins are nucleoporins with an important role in hormone signaling and development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001198200.2

Supported by ESTs:

NM_001333042.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of timing of transition from vegetative to reproductive phase	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to auxin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cold	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SUPPRESSOR OF AUXIN RESISTANCE1

NP_001185129.1

SUPPRESSOR OF AUXIN RESISTANCE1 (SAR1); INVOLVED IN: mRNA export from nucleus, response to auxin stimulus, developmental process; LOCATED IN: nuclear membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleoporin Nup120/160 (InterPro:IPR021717).

NP_001319133.1

SUPPRESSOR OF AUXIN RESISTANCE1 (SAR1); CONTAINS InterPro DOMAIN/s: Nucleoporin Nup120/160 (InterPro:IPR021717); Has 209 Blast hits to 198 proteins in 81 species: Archae - 0; Bacteria - 0; Metazoa - 119; Fungi - 29; Plants - 47; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

12109561..12118861 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001333042.1 → NP_001319133.1 SUPPRESSOR OF AUXIN RESISTANCE1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WFA0, A0A178WFJ2

Conserved Domains (2) summary

pfam11715
Location:54 → 535

Nup160; Nucleoporin Nup120/160

pfam17238
Location:550 → 741

DUF5311; Family of unknown function (DUF5311)
NM_001198200.2 → NP_001185129.1 SUPPRESSOR OF AUXIN RESISTANCE1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185129.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WF46, A0A178WFJ2

Conserved Domains (2) summary

pfam11715
Location:54 → 539

Nup160; Nucleoporin Nup120/160

pfam17238
Location:554 → 745

DUF5311; Family of unknown function (DUF5311)