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    Stmp1 short transmembrane mitochondrial protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689574, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Stmp1provided by RGD
    Official Full Name
    short transmembrane mitochondrial protein 1provided by RGD
    Primary source
    RGD:1591053
    See related
    EnsemblRapid:ENSRNOG00000067332 AllianceGenome:RGD:1591053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex assembly; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrial intermembrane space and mitochondrial outer membrane. Predicted to be active in mitochondrial inner membrane. Orthologous to human STMP1 (short transmembrane mitochondrial protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 338.5), Spleen (RPKM 333.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stmp1 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64894663..64904495)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63927523..63937355)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (62780596..62790428)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 205 Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene solute carrier family 13 member 4 Neighboring gene uncharacterized LOC134486753 Neighboring gene family with sequence similarity 180, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of membrane proteins by tandem mass spectrometry of protein ions. Carroll J, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17720804, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respirasome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    short transmembrane mitochondrial protein 1
    Names
    PL-5283 protein
    uncharacterized protein C7orf73 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195503.2 → NP_001182432.1  short transmembrane mitochondrial protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      M0R474
      Conserved Domains (1) summary
      pfam15054
      Location:4 → 55
      DUF4535; Domain of unknown function (DUF4535)

    2. NM_001195504.2 → NP_001182433.1  short transmembrane mitochondrial protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001182433.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IEN9
      Related
      ENSRNOP00000105706.1, ENSRNOT00000106740.2
      Conserved Domains (1) summary
      pfam15054
      Location:4 → 44
      DUF4535; Domain of unknown function (DUF4535)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      64894663..64904495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286720.1 → XP_063142790.1  short transmembrane mitochondrial protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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