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    4CL1 4-coumarate:CoA ligase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841593, updated on 18-Sep-2024

    Summary

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    Official Symbol
    4CL1
    Official Full Name
    4-coumarate:CoA ligase 1
    Primary source
    TAIR:AT1G51680
    Locus tag
    AT1G51680
    See related
    Araport:AT1G51680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-COUMARATE:COA LIGASE; 4-coumarate:CoA ligase 1; 4-COUMARATE:COA LIGASE 1; 4CL.1; ARABIDOPSIS THALIANA 4-COUMARATE:COA LIGASE 1; AT4CL1; F19C24.11; F19C24_11
    Summary
    encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. In addition to 4-coumarate, it also converts ferulate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, ferulic acid, caffeic acid and 5-OH-ferulic acid. At4CL1 was unable to use sinapic acid as substrate.
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    Genomic context

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    See 4CL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (19158746..19161737, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ATP synthase epsilon chain Neighboring gene mitogen-activated protein kinase kinase 4 Neighboring gene uncharacterized protein Neighboring gene protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Four Isoforms of Arabidopsis 4-Coumarate:CoA Ligase Have Overlapping yet Distinct Roles in Phenylpropanoid Metabolism. Li Y, et al. Plant Physiol, 2015 Dec. PMID 26491147, Free PMC Article
    2. Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms. Ehlting J, et al. Plant J, 1999 Jul. PMID 10417722
    3. Protein-protein and protein-membrane associations in the lignin pathway. Bassard JE, et al. Plant Cell, 2012 Nov. PMID 23175744, Free PMC Article
    4. SND1, a NAC domain transcription factor, is a key regulator of secondary wall synthesis in fibers of Arabidopsis. Zhong R, et al. Plant Cell, 2006 Nov. PMID 17114348, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 4CL1 or 4CL2 is required for normal plant growth.
      Title: Four Isoforms of Arabidopsis 4-Coumarate:CoA Ligase Have Overlapping yet Distinct Roles in Phenylpropanoid Metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001084228.1
    NM_104046.3
    NM_179462.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-coumarate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phenylpropanoid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    4-coumarate:CoA ligase 1
    NP_001077697.1
    • 4-coumarate:CoA ligase 1 (4CL1); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 83069 Blast hits to 75791 proteins in 3772 species: Archae - 1181; Bacteria - 53827; Metazoa - 3457; Fungi - 4480; Plants - 2791; Viruses - 1; Other Eukaryotes - 17332 (source: NCBI BLink).
    NP_175579.1
    • 4-coumarate:CoA ligase 1 (4CL1); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 83980 Blast hits to 76655 proteins in 3756 species: Archae - 1185; Bacteria - 53552; Metazoa - 3476; Fungi - 4550; Plants - 2810; Viruses - 1; Other Eukaryotes - 18406 (source: NCBI BLink).
    NP_849793.1
    • 4-coumarate:CoA ligase 1 (4CL1); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 80831 Blast hits to 73675 proteins in 3786 species: Archae - 1165; Bacteria - 53622; Metazoa - 3406; Fungi - 4376; Plants - 2578; Viruses - 1; Other Eukaryotes - 15683 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19158746..19161737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104046.3 → NP_175579.1  4-coumarate:CoA ligase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42524, Q8RY63
      UniProtKB/TrEMBL
      A0A178W9C1, A0A1P8SNN0, A0A384L454, B1GUV7
      Conserved Domains (1) summary
      PLN02246
      Location:16 → 560
      PLN02246; 4-coumarate--CoA ligase

    2. NM_001084228.1 → NP_001077697.1  4-coumarate:CoA ligase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MS69, B1GUV7
      Conserved Domains (2) summary
      cd05904
      Location:34 → 525
      4CL; 4-Coumarate-CoA Ligase (4CL)
      PLN02246
      Location:16 → 525
      PLN02246; 4-coumarate--CoA ligase

    3. NM_179462.2 → NP_849793.1  4-coumarate:CoA ligase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1GUV0, B1GUV7
      Conserved Domains (2) summary
      cd05904
      Location:34 → 489
      4CL; 4-Coumarate-CoA Ligase (4CL)
      pfam00501
      Location:44 → 464
      AMP-binding; AMP-binding enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42524.1

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