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    CTC1 conserved telomere maintenance component 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826554, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CTC1
    Official Full Name
    conserved telomere maintenance component 1
    Primary source
    TAIR:AT4G09680
    Locus tag
    AT4G09680
    See related
    Araport:AT4G09680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCTC1; conserved telomere maintenance component 1; F17A8.30; F17A8_30
    Summary
    Encodes CTC1 (Conserved Telomere Maintenance Component 1) involved in telomere maintenance.
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    Genomic context

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    See CTC1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (6116699..6123304)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene zinc finger MYM-type-like protein Neighboring gene Oxidoreductase family protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Nested PCR Telomere Fusion Assay Highlights the Widespread End-Capping Protection of Arabidopsis CTC1. Vaquero-Sedas MI, et al. Int J Mol Sci, 2024 Jan 4. PMID 38203842, Free PMC Article
    2. Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction. Beilstein MA, et al. Mol Biol Evol, 2015 May. PMID 25697340, Free PMC Article
    3. ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis. Boltz KA, et al. Mol Biol Cell, 2012 Apr. PMID 22357613, Free PMC Article
    4. Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Surovtseva YV, et al. Mol Cell, 2009 Oct 23. PMID 19854131, Free PMC Article
    5. POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis. Renfrew KB, et al. PLoS Genet, 2014 Oct. PMID 25329641, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Nested PCR Telomere Fusion Assay Highlights the Widespread End-Capping Protection of Arabidopsis CTC1.
      Title: A Nested PCR Telomere Fusion Assay Highlights the Widespread End-Capping Protection of Arabidopsis CTC1.
    2. POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.
      Title: POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.
    3. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis
      Title: ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.
    4. CTC1 participates in telomere maintenance in diverse species and that a CST-like complex is required for telomere integrity in multicellular organisms. [CTC1]
      Title: Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001125488.2
    NM_117036.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    conserved telomere maintenance component 1
    NP_001118960.1
    • conserved telomere maintenance component 1 (CTC1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: telomere maintenance; LOCATED IN: chromosome, telomeric region; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_192706.5
    • conserved telomere maintenance component 1 (CTC1); Has 50 Blast hits to 32 proteins in 13 species: Archae - 0; Bacteria - 3; Metazoa - 1; Fungi - 0; Plants - 46; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      6116699..6123304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340628.1 → NP_001329552.1  conserved telomere maintenance component 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UZV0, A0A1P8B816

    2. NM_001340629.1 → NP_001329551.1  conserved telomere maintenance component 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4T9, D0EL35, Q0WL26, Q9SZ84
      UniProtKB/TrEMBL
      A0A5S9XQS0

    3. NM_001125488.2 → NP_001118960.1  conserved telomere maintenance component 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0EL35
      Conserved Domains (1) summary
      pfam15491
      Location:62 → 343
      CTC1_2; CST, telomere maintenance, complex subunit CTC1

    4. NM_117036.5 → NP_192706.5  conserved telomere maintenance component 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192706.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XQS0, F4JKR3
      Conserved Domains (1) summary
      pfam15491
      Location:62 → 343
      CTC1_2; CST, telomere maintenance, complex subunit CTC1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0EL35.2

    Gene LinkOut

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