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    NRT1.8 NITRATE TRANSPORTER 1.8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828255, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRT1.8
    Official Full Name
    NITRATE TRANSPORTER 1.8
    Primary source
    TAIR:AT4G21680
    Locus tag
    AT4G21680
    See related
    Araport:AT4G21680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtNPF7.2; F17L22.140; F17L22_140; NITRATE TRANSPORTER 1.8; NPF7.2; NRT1/ PTR family 7.2
    Summary
    Encodes a nitrate transporter (NRT1.8). Functions in nitrate removal from the xylem sap. Mediates cadmium tolerance.
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    Genomic context

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    See NRT1.8 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (11517353..11519805, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Subtilase family protein Neighboring gene proline-rich spliceosome-associated (PSP) family protein Neighboring gene C-terminal domain phosphatase-like 1 Neighboring gene ncRNA Neighboring gene gibberellin 3-oxidase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance. Li JY, et al. Plant Cell, 2010 May. PMID 20501909, Free PMC Article
    2. The Arabidopsis ethylene/jasmonic acid-NRT signaling module coordinates nitrate reallocation and the trade-off between growth and environmental adaptation. Zhang GB, et al. Plant Cell, 2014 Oct. PMID 25326291, Free PMC Article
    3. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that ethylene (ET) and jasmonic acid (JA)-nitrate transporters NRT1.8 and NRT1.5 signaling affect the crosstalk between stress-initiated nitrate allocation to roots (SINAR) and the environment.
      Title: The Arabidopsis ethylene/jasmonic acid-NRT signaling module coordinates nitrate reallocation and the trade-off between growth and environmental adaptation.
    2. Data suggests that NRT1.8-regulated nitrate distribution plays an important role in Cd(2+) tolerance. [NRT1.8]
      Title: The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118288.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nitrate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nitrate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NITRATE TRANSPORTER 1.8
    NP_193899.2
    • NITRATE TRANSPORTER 1.8 (NRT1.8); FUNCTIONS IN: transporter activity, nitrate transmembrane transporter activity; INVOLVED IN: response to cadmium ion, oligopeptide transport, response to nitrate; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: nitrate transporter 1.5 (TAIR:AT1G32450.1); Has 7448 Blast hits to 7020 proteins in 1418 species: Archae - 0; Bacteria - 3502; Metazoa - 786; Fungi - 405; Plants - 2210; Viruses - 0; Other Eukaryotes - 545 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11517353..11519805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118288.4 → NP_193899.2  NITRATE TRANSPORTER 1.8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193899.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXN2, Q9SVS9
      UniProtKB/TrEMBL
      A0A178UX66, A0A5S9XV03
      Conserved Domains (1) summary
      cl21472
      Location:100 → 536
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXN2.2

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