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    La1 La protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829408, updated on 18-Sep-2024

    Summary

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    Official Symbol
    La1
    Official Full Name
    La protein 1
    Primary source
    TAIR:AT4G32720
    Locus tag
    AT4G32720
    See related
    Araport:AT4G32720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLa1; F4D11.80; F4D11_80; La protein 1
    Summary
    Encodes AtLa1, a member of the highly abundant phosphoprotein La proteins. Predominantly localized to the nucleoplasm and was also detected in the nucleolar cavity. Has RNA binding activity. Required for normal ribosome biogenesis and embryogenesis.
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    Genomic context

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    See La1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (15787194..15789996)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene SCR-like 24 Neighboring gene Homeodomain-like protein Neighboring gene uncharacterized protein Neighboring gene ENTH/VHS/GAT family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A bona fide La protein is required for embryogenesis in Arabidopsis thaliana. Fleurdépine S, et al. Nucleic Acids Res, 2007. PMID 17459889, Free PMC Article
    2. The AtMC4 regulates the stem cell homeostasis in Arabidopsis by catalyzing the cleavage of AtLa1 protein in response to environmental hazards. Huang Y, et al. Plant Sci, 2018 Jan. PMID 29241568
    3. AtLa1 protein initiates IRES-dependent translation of WUSCHEL mRNA and regulates the stem cell homeostasis of Arabidopsis in response to environmental hazards. Cui Y, et al. Plant Cell Environ, 2015 Oct. PMID 25764476
    4. Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing. Palm D, et al. Nucleic Acids Res, 2019 Feb 28. PMID 30576513, Free PMC Article
    5. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The AtMC4 protein regulates stem cell homeostasis by catalyzing the cleavage of AtLa1 protein in response to environmental hazards.
      Title: The AtMC4 regulates the stem cell homeostasis in Arabidopsis by catalyzing the cleavage of AtLa1 protein in response to environmental hazards.
    2. The stem cell niche in Arabidopsis copes with environmental hazards by enhancing the IRES-dependent translation of WUS mRNA under the control of the AtLa1 protein.
      Title: AtLa1 protein initiates IRES-dependent translation of WUSCHEL mRNA and regulates the stem cell homeostasis of Arabidopsis in response to environmental hazards.
    3. Inactivation of AtLa1 (At4g32720) function is lethal and leads to an early developmental arrest of the embryo.
      Title: A bona fide La protein is required for embryogenesis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001036700.2
    NM_119425.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sno(s)RNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    La protein 1
    NP_001031777.1
    • La protein 1 (La1); FUNCTIONS IN: RNA binding; INVOLVED IN: embryo development, ribosome biogenesis; LOCATED IN: nucleoplasm, cell wall; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Lupus La protein (InterPro:IPR002344), RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677), RNA-binding motif (InterPro:IPR014886); BEST Arabidopsis thaliana protein match is: RNA recognition motif (RRM)-containing protein (TAIR:AT1G79880.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_567904.1
    • La protein 1 (La1); FUNCTIONS IN: RNA binding; INVOLVED IN: embryo development, ribosome biogenesis; LOCATED IN: nucleoplasm, cell wall; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Lupus La protein (InterPro:IPR002344), RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677), RNA-binding motif (InterPro:IPR014886); BEST Arabidopsis thaliana protein match is: RNA recognition motif (RRM)-containing protein (TAIR:AT1G79880.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15787194..15789996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119425.5 → NP_567904.1  La protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JV47, O65529, Q8L7E4, Q93ZV7
      UniProtKB/TrEMBL
      A0A178V700, A0A5S9Y084
      Conserved Domains (3) summary
      cd08030
      Location:10 → 99
      LA_like_plant; La-motif domain of plant proteins similar to the La autoantigen
      cd12291
      Location:117 → 189
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      cl17169
      Location:316 → 388
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001036700.2 → NP_001031777.1  La protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZV7
      Conserved Domains (4) summary
      cd08030
      Location:10 → 99
      LA_like_plant; La-motif domain of plant proteins similar to the La autoantigen
      COG0724
      Location:114 → 237
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12291
      Location:117 → 189
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      cd12292
      Location:311 → 376
      RRM2_La_like; RNA recognition motif 2 in La autoantigen (La or SS-B or LARP3), La-related protein 7 (LARP7 or PIP7S) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93ZV7.1

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