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    ADT4 arogenate dehydratase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823601, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADT4
    Official Full Name
    arogenate dehydratase 4
    Primary source
    TAIR:AT3G44720
    Locus tag
    AT3G44720
    See related
    Araport:AT3G44720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    arogenate dehydratase 4
    Summary
    Encodes a plastid-localized arogenate dehydratase involved in phenylalanine biosynthesis. Not less than six genes encoding ADT were identified in the Arabidopsis genome: ADT1 [At1g11790]; ADT2 [At3g07630]; ADT3 [At2g27820]; ADT4 [At3g44720]; ADT5 [At5g22630]; and ADT6 [At1g08250].
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    Genomic context

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    See ADT4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (16271511..16273413)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Plant thionin family protein Neighboring gene miscRNA Neighboring gene kinesin-like protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism. Höhner R, et al. Plant Physiol, 2018 May. PMID 29523714, Free PMC Article
    2. Tyrosine and phenylalanine are synthesized within the plastids in Arabidopsis. Rippert P, et al. Plant Physiol, 2009 Mar. PMID 19136569, Free PMC Article
    3. Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases. Cho MH, et al. J Biol Chem, 2007 Oct 19. PMID 17726025
    4. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADT4 role in photosynthesis and secondary metabolism.
      Title: Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114340.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arogenate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prephenate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    arogenate dehydratase 4
    NP_190058.1
    • arogenate dehydratase 4 (ADT4); CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: arogenate dehydratase 5 (TAIR:AT5G22630.1); Has 7069 Blast hits to 7066 proteins in 2218 species: Archae - 179; Bacteria - 3950; Metazoa - 0; Fungi - 120; Plants - 261; Viruses - 0; Other Eukaryotes - 2559 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16271511..16273413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114340.4 → NP_190058.1  arogenate dehydratase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22241
      UniProtKB/TrEMBL
      A0A5S9XHZ0
      Conserved Domains (3) summary
      cd04905
      Location:315 → 410
      ACT_CM-PDT; C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme
      PLN02317
      Location:29 → 416
      PLN02317; arogenate dehydratase
      cd13631
      Location:124 → 305
      PBP2_Ct-PDT_like; Catalytic domain of prephenate dehydratase from Chlorobium tepidum and similar proteins, subgroup 2; the type 2 periplasmic binding protein fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22241.1

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