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    PEN3 PTEN 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824173, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEN3
    Official Full Name
    PTEN 3
    Primary source
    TAIR:AT3G50110
    Locus tag
    AT3G50110
    See related
    Araport:AT3G50110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana phosphatase and TENsin homolog deleted on chromosome ten 3; ATPEN3; phosphatase and TENsin homolog deleted on chromosome ten 2B; PTEN 3; PTEN2B
    Summary
    Encodes a phosphatase with low in vitro tyrosine phosphatase activity that is NOT capable of dephosphorylating in vitro the 3'phosphate group of PI3P, PI(3,4)P2.
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    Genomic context

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    See PEN3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (18580609..18584813, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene VIER F-box protein 2 Neighboring gene Exonuclease family protein Neighboring gene small RNA degrading nuclease 1 Neighboring gene transmembrane protein, putative (DUF247) Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel class of PTEN protein in Arabidopsis displays unusual phosphoinositide phosphatase activity and efficiently binds phosphatidic acid. Pribat A, et al. Biochem J, 2012 Jan 1. PMID 21864294
    2. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114871.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    PTEN 3
    NP_566929.1
    • PTEN 3 (PEN3); FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation, dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Phosphatase tensin type (InterPro:IPR014019), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Tensin phosphatase, C2 domain (InterPro:IPR014020); BEST Arabidopsis thaliana protein match is: PTEN 2 (TAIR:AT3G19420.1); Has 4656 Blast hits to 2326 proteins in 274 species: Archae - 2; Bacteria - 2303; Metazoa - 1189; Fungi - 507; Plants - 170; Viruses - 4; Other Eukaryotes - 481 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18580609..18584813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114871.3 → NP_566929.1  PTEN 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H106, Q9SN07
      UniProtKB/TrEMBL
      A0A178VJS2, A0A7G2EVA6
      Conserved Domains (1) summary
      cd14509
      Location:199 → 363
      PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H106.1

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