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    SPC98 spindle pole body component 98 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830557, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPC98
    Official Full Name
    spindle pole body component 98
    Primary source
    TAIR:AT5G06680
    Locus tag
    AT5G06680
    See related
    Araport:AT5G06680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GAMMA TUBULIN COMPLEX PROTEIN 3; ATGCP3; ATSPC98; GAMMA TUBULIN COMPLEX PROTEIN 3; GCP3; MPH15.2; MPH15_2; spindle pole body component 98; SPINDLE POLE BODY COMPONENT 98
    Summary
    Encodes protein similar to yeast SCP98. Yeast SCP98 is essential for the microtubule nucleation activity of the gamma-tubulin ring complexes. Enriched at the post-cytokinetic cell edges in leaves and roots.
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    Genomic context

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    See SPC98 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (2056528..2059859)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene transmembrane/coiled-coil protein (Protein of unknown function DUF106, transmembrane) Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene tRNA-Ser Neighboring gene WCRKC thioredoxin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant Spc98p homologue colocalizes with gamma-tubulin at microtubule nucleation sites and is required for microtubule nucleation. Erhardt M, et al. J Cell Sci, 2002 Jun 1. PMID 12006626
    2. The Arabidopsis AtGCD3 protein is a glucosylceramidase that preferentially hydrolyzes long-acyl-chain glucosylceramides. Dai GY, et al. J Biol Chem, 2020 Jan 17. PMID 31819005, Free PMC Article
    3. Cell edges accumulate gamma tubulin complex components and nucleate microtubules following cytokinesis in Arabidopsis thaliana. Ambrose C, et al. PLoS One, 2011. PMID 22110647, Free PMC Article
    4. Microtubule and katanin-dependent dynamics of microtubule nucleation complexes in the acentrosomal Arabidopsis cortical array. Nakamura M, et al. Nat Cell Biol, 2010 Nov. PMID 20935636
    5. A mutation in the Arabidopsis gamma-tubulin-containing complex causes helical growth and abnormal microtubule branching. Nakamura M, et al. J Cell Sci, 2009 Jul 1. PMID 19509058

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis AtGCD3 protein is a glucosylceramidase that preferentially hydrolyzes long-acyl-chain glucosylceramides.
      Title: The Arabidopsis AtGCD3 protein is a glucosylceramidase that preferentially hydrolyzes long-acyl-chain glucosylceramides.
    2. gamma tubulin nucleation complex (GCP2 and GCP3) localize at distinct sites along the outer periclinal edge of newly formed crosswalls
      Title: Cell edges accumulate gamma tubulin complex components and nucleate microtubules following cytokinesis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120751.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule nucleation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to nematode IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spindle pole body component 98
    NP_196286.1
    • spindle pole body component 98 (SPC98); CONTAINS InterPro DOMAIN/s: Spc97/Spc98 (InterPro:IPR007259), Gamma tubulin complex protein 3 (InterPro:IPR015697); BEST Arabidopsis thaliana protein match is: Spc97 / Spc98 family of spindle pole body (SBP) component (TAIR:AT5G17410.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2056528..2059859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120751.4 → NP_196286.1  spindle pole body component 98 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FG37
      UniProtKB/TrEMBL
      A0A178UFG2, A0A5S9Y1Z7, A0A654FYV7
      Conserved Domains (2) summary
      pfam04130
      Location:499 → 831
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:190 → 493
      GCP_N_terminal; Gamma tubulin complex component N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FG37.1

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