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    ATXR6 TRITHORAX-RELATED PROTEIN 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832503, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATXR6
    Official Full Name
    TRITHORAX-RELATED PROTEIN 6
    Primary source
    TAIR:AT5G24330
    Locus tag
    AT5G24330
    See related
    Araport:AT5G24330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS TRITHORAX-RELATED PROTEIN 6; MOP9.7; MOP9_7; SDG34; SET DOMAIN PROTEIN 34
    Summary
    Encodes a SET-domain protein, a H3K27 monomethyltransferases required for chromatin structure and gene silencing. Regulates heterochromatic DNA replication. Contains a PCNA-binding domain. ATXR6 accumulates preferentially during the late G1 or S phase, suggesting that it plays a role in cell-cycle regulation or progression.
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    Genomic context

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    See ATXR6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (8295110..8297159, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene 3'-5' exonuclease domain-containing protein Neighboring gene neuroblastoma-amplified sequence protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis. Potok ME, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35027454, Free PMC Article
    2. ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle. Davarinejad H, et al. J Mol Biol, 2019 Mar 29. PMID 30826376
    3. Dual function of MIPS1 as a metabolic enzyme and transcriptional regulator. Latrasse D, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23341037, Free PMC Article
    4. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Jacob Y, et al. Nature, 2010 Aug 19. PMID 20631708, Free PMC Article
    5. ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Jacob Y, et al. Nat Struct Mol Biol, 2009 Jul. PMID 19503079, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis.
      Title: The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis.
    2. ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle.
      Title: ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle.
    3. mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead to re-replication of specific genomic locations
      Title: Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases.
    4. These results indicate that ATXR5 and ATXR6 form a new class of H3K27 methyltransferases and that H3K27me1 represents a previously uncharacterized pathway required for transcriptional repression in Arabidopsis.
      Title: ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.
    5. ATXR5 and ARXR6 interact with proliferating cell nuclear antigen (PCNA) and are associated with a role in the cell cycle or DNA replication. [ATXR6]
      Title: Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122341.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H3K27 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anther dehiscence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    TRITHORAX-RELATED PROTEIN 6
    NP_197821.1
    • ARABIDOPSIS TRITHORAX-RELATED PROTEIN 6 (ATXR6); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (TAIR:AT5G09790.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8295110..8297159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122341.3 → NP_197821.1  TRITHORAX-RELATED PROTEIN 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197821.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FNE9
      UniProtKB/TrEMBL
      A0A178UMD0, A0A5S9Y6V5
      Conserved Domains (2) summary
      cd15543
      Location:35 → 79
      PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
      cd10539
      Location:211 → 349
      SET_ATXR5_6-like; SET domain found in fungal protein lysine methyltransferase SET5 and similar protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNE9.1

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