U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GRF3 general regulatory factor 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833836, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GRF3
    Official Full Name
    general regulatory factor 3
    Primary source
    TAIR:AT5G38480
    Locus tag
    AT5G38480
    See related
    Araport:AT5G38480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    general regulatory factor 3; GF14PSI ISOFORM; MXI10.21; MXI10_21; RCI1
    Summary
    general regulatory factor, a 14-3-3 gene
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GRF3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (15409684..15411601)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Rad23 UV excision repair protein family Neighboring gene ncRNA Neighboring gene B3 domain protein (DUF313) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Robust increase of leaf size by Arabidopsis thaliana GRF3-like transcription factors under different growth conditions. Beltramino M, et al. Sci Rep, 2018 Sep 7. PMID 30194309, Free PMC Article
    2. Phosphate differentially regulates 14-3-3 family members and GRF9 plays a role in Pi-starvation induced responses. Cao A, et al. Planta, 2007 Oct. PMID 17598127
    3. A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism. Piya S, et al. J Exp Bot, 2020 Feb 19. PMID 31701146, Free PMC Article
    4. Dimerization of Arabidopsis 14-3-3 proteins: structural requirements within the N-terminal domain and effect of calcium. Abarca D, et al. FEBS Lett, 1999 Dec 3. PMID 10622729
    5. Complex feedback regulations govern the expression of miRNA396 and its GRF target genes. Hewezi T, et al. Plant Signal Behav, 2012 Jul. PMID 22751317, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.
      Title: A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.
    2. findings indicate that rGRF3 can increase plant organ size under both normal and stress conditions and is a valuable tool for biotechnological applications.
      Title: Robust increase of leaf size by Arabidopsis thaliana GRF3-like transcription factors under different growth conditions.
    3. cuc1 grf1/2/3, cuc2 grf1/2/3, and cuc3 grf1/2/3 quadruple mutants showed dramatic increases in cotyledon fusion as well as floral organ fusion.
      Title: Genetic interaction between GROWTH-REGULATING FACTOR and CUP-SHAPED COTYLEDON in organ separation.
    4. RCI1A connects the low-temperature response with ET biosynthesis to modulate constitutive freezing tolerance and cold acclimation in Arabidopsis.
      Title: The Arabidopsis 14-3-3 protein RARE COLD INDUCIBLE 1A links low-temperature response and ethylene biosynthesis to regulate freezing tolerance and cold acclimation.
    5. Homeostasis between miR396 and the target genes GRF1 and GRF3 is established through reciprocal feedback regulation.
      Title: Complex feedback regulations govern the expression of miRNA396 and its GRF target genes.
    6. Work elucidates how 14-3-3s function as modulators of plant N and S metabolic pathways.
      Title: 14-3-3 proteins fine-tune plant nutrient metabolism.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001344251.1
    NM_001344252.1
    NM_123209.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphorylated amino acid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nitrogen starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to potassium ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to freezing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    general regulatory factor 3
    NP_001318697.1
    • general regulatory factor 3 (GRF3); FUNCTIONS IN: protein phosphorylated amino acid binding, ATP binding; LOCATED IN: mitochondrion, cell wall, chloroplast, plasma membrane, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: general regulatory factor 7 (TAIR:AT3G02520.1); Has 2749 Blast hits to 2739 proteins in 391 species: Archae - 0; Bacteria - 6; Metazoa - 1263; Fungi - 337; Plants - 766; Viruses - 0; Other Eukaryotes - 377 (source: NCBI BLink).
    NP_568557.1
    • general regulatory factor 3 (GRF3); FUNCTIONS IN: protein phosphorylated amino acid binding, ATP binding; LOCATED IN: mitochondrion, cell wall, chloroplast, plasma membrane, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: general regulatory factor 7 (TAIR:AT3G02520.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      15409684..15411601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123209.4 → NP_568557.1  general regulatory factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KBI7, P42644, Q945L2
      UniProtKB/TrEMBL
      A0A178UA42, A0A5S9Y9F6
      Conserved Domains (1) summary
      cl02098
      Location:4 → 240
      14-3-3; 14-3-3 domain

    2. NM_001344252.1 → NP_001332624.1  general regulatory factor 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y9F6

    3. NM_001344251.1 → NP_001318697.1  general regulatory factor 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y9F6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42644.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools