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    SAD1 Small nuclear ribonucleoprotein family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834945, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAD1
    Official Full Name
    Small nuclear ribonucleoprotein family protein
    Primary source
    TAIR:AT5G48870
    Locus tag
    AT5G48870
    See related
    Araport:AT5G48870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLSM5; AtSAD1; K24G6.21; K24G6_21; LSM5; SM-like 5; SUPERSENSITIVE TO ABA AND DROUGHT 1
    Summary
    SAD1 encodes a polypeptide similar to multifunctional Sm-like snRNP proteins that are required for mRNA splicing, export, and degradation. Mutation in this gene increases plant sensitivity to drought stress and ABA in seed germination, root growth, and the expression of some stress-responsive genes.
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    Genomic context

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    See SAD1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (19813346..19814554)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene peroxisomal 3-keto-acyl-CoA thiolase 2 Neighboring gene C2H2-like zinc finger protein Neighboring gene Pectin lyase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic regulation of genome-wide pre-mRNA splicing and stress tolerance by the Sm-like protein LSm5 in Arabidopsis. Cui P, et al. Genome Biol, 2014 Jan 7. PMID 24393432, Free PMC Article
    2. Modulation of abscisic acid signal transduction and biosynthesis by an Sm-like protein in Arabidopsis. Xiong L, et al. Dev Cell, 2001 Dec. PMID 11740939
    3. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124264.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Small nuclear ribonucleoprotein family protein
    NP_199698.1
    • SUPERSENSITIVE TO ABA AND DROUGHT 1 (SAD1); CONTAINS InterPro DOMAIN/s: Like-Sm ribonucleoprotein (LSM) domain (InterPro:IPR001163), Like-Sm ribonucleoprotein (LSM) domain, eukaryotic/archaea-type (InterPro:IPR006649), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19813346..19814554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124264.4 → NP_199698.1  Small nuclear ribonucleoprotein family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WMZ9, Q9FKB0
      UniProtKB/TrEMBL
      A0A178USD1, A0A5S9YCT5
      Conserved Domains (1) summary
      cd01732
      Location:7 → 82
      LSm5; Like-Sm protein 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKB0.1

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