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    ALC basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836846, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALC
    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT5G67110
    Locus tag
    AT5G67110
    See related
    Araport:AT5G67110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALCATRAZ; K21H1.7; K21H1_7
    Summary
    encodes a myc/bHLH transcription factor-like protein. Gene product is involved in fruit dehiscence. Mutant siliques fail to dehisce.
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    Genomic context

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    See ALC in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (26785106..26786431, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ralf-like 34 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene Subtilisin-like serine endopeptidase family protein Neighboring gene DNA-directed DNA polymerase Neighboring gene RING/U-box superfamily protein Neighboring gene PLC-like phosphodiesterases superfamily protein Neighboring gene F-box/RNI-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis myc/bHLH gene ALCATRAZ enables cell separation in fruit dehiscence. Rajani S, et al. Curr Biol, 2001 Dec 11. PMID 11747817
    2. SPATULA and ALCATRAZ, are partially redundant, functionally diverging bHLH genes required for Arabidopsis gynoecium and fruit development. Groszmann M, et al. Plant J, 2011 Dec. PMID 21801252
    3. Novel nuclear protein ALC-INTERACTING PROTEIN1 is expressed in vascular and mesocarp cells in Arabidopsis. Wang F, et al. J Integr Plant Biol, 2008 Jul. PMID 18713402
    4. Conservation of fruit dehiscence pathways between Lepidium campestre and Arabidopsis thaliana sheds light on the regulation of INDEHISCENT. Lenser T, et al. Plant J, 2013 Nov. PMID 24004048
    5. Gibberellins control fruit patterning in Arabidopsis thaliana. Arnaud N, et al. Genes Dev, 2010 Oct 1. PMID 20889713, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Over-expression of ALCATRAZ can partially compensate for a loss of SPATULA function, and over-expression of SPATULA can fully compensate for loss of ALCATRAZ function.
      Title: SPATULA and ALCATRAZ, are partially redundant, functionally diverging bHLH genes required for Arabidopsis gynoecium and fruit development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085341.1
    NM_001085342.1
    NM_126111.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fruit dehiscence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_001078810.1
    • ALCATRAZ (ALC); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G00050.1); Has 515 Blast hits to 509 proteins in 24 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 514; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_001078811.1
    • ALCATRAZ (ALC); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G36930.1); Has 312 Blast hits to 312 proteins in 18 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 312; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_201512.1
    • ALCATRAZ (ALC); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G36930.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26785106..26786431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126111.4 → NP_201512.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201512.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRE6, A8MS60, Q9FHA2
      UniProtKB/TrEMBL
      A0A5S9YHR0, A0A654GEV2, Q680B1, Q8LFU9
      Conserved Domains (1) summary
      cd11445
      Location:94 → 156
      bHLH_AtPIF_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins

    2. NM_001085342.1 → NP_001078811.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q680B1, Q8LFU9
      Conserved Domains (1) summary
      smart00353
      Location:91 → 126
      HLH; helix loop helix domain

    3. NM_001085341.1 → NP_001078810.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UQY8
      Conserved Domains (1) summary
      cd00083
      Location:98 → 137
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FHA2.1

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