LEC2 AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LEC2
Official Full Name: AP2/B3-like transcriptional factor family protein
Primary source: TAIR:AT1G28300
Locus tag: AT1G28300
See related: Araport:AT1G28300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtLEC2; F3H9.5; F3H9_5; LEAFY COTYLEDON 2
Summary: Transcription factor that contains a B3 domain, a DNA-binding motif unique to plants and characteristic of several transcription factors. Plays critical roles both early and late during embryo development. LEC2 RNA accumulates primarily during seed development. LEC2 is required for the maintenance of suspensor morphology, specification of cotyledon identity, progression through the maturation phase, and suppression of premature germination. It establishes a cellular environment sufficient to initiate embryo development - ectopic, postembryonic expression of LEC2 in transgenic plants induces the formation of somatic embryos and other organ-like structures and often confers embryonic characteristics to seedlings and to reproductive and vegetative organs of mature plants.
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Genomic context

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See LEC2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 6

Sequence:: Chromosome: 1; NC_003070.9 (9896867..9899876, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiple transcription factors of Arabidopsis thaliana that are activated by LEAFY COTYLEDON 2 regulate triacylglycerol biosynthesis.
Title: Multiple transcription factors of Arabidopsis thaliana that are activated by LEAFY COTYLEDON 2 regulate triacylglycerol biosynthesis.
E2FA directly regulates LEC2, and mutation at the consensus E2F-binding site in the LEC2 promoter de-represses its activity during the proliferative stage of seed development
Title: E2FA and E2FB transcription factors coordinate cell proliferation with seed maturation.
the mutations of key amino acids for the function of LEC1 in planta (D86K) prevented the interaction with LEC2. These results provide molecular evidences for the binding of LEC1 to B2-domain containing transcription factors, to form heteromers, involved in the control of gene expression.
Title: LEC1 (NF-YB9) directly interacts with LEC2 to control gene expression in seed.
LEAFY COTYLEDON2 (LEC2) was identified as an interacting factor of FUS3, and demonstrated that these two homologous B3 transcription factors interact to bind to the auxin biosynthesis gene YUCCA4 (YUC4) and synergistically activate its transcription during lateral roots formation.
Title: FUSCA3 interacting with LEAFY COTYLEDON2 controls lateral root formation through regulating YUCCA4 gene expression in Arabidopsis thaliana.
senescence-inducible and triggers the key metabolic steps that increase triacylglycerol accumulation in leaves
Title: Senescence-inducible LEC2 enhances triacylglycerol accumulation in leaves without negatively affecting plant growth.
LEC1, LEC2 , and FUSCA3 transcripts are candidate targets of VAL1, acting through epigenetic and/or transcriptional repression.
Title: Potential targets of VIVIPAROUS1/ABI3-LIKE1 (VAL1) repression in developing Arabidopsis thaliana embryos.
This study examined the role of ABSCISIC ACID INSENSITIVE3 (ABI3), FUSCA3 (FUS3) and LEAFY COTYLEDON2 (LEC2), in the production of seed reserves in Arabidopsis.
Title: Complementation of Seed Maturation Phenotypes by Ectopic Expression of ABSCISIC ACID INSENSITIVE3, FUSCA3 and LEAFY COTYLEDON2 in Arabidopsis.
LEC2 overexpression modifies the morphology and anatomy of leaves by promoting differentiation toward an embryonic pathway.
Title: Following vegetative to embryonic cellular changes in leaves of Arabidopsis overexpressing LEAFY COTYLEDON2.
The analysis indicated that YUCCAs and TAA1, working in the IPA-YUC auxin biosynthesis pathway, are associated with SE induction, and that the expression of three YUCCA genes (YUC1, YUC4 and YUC10) is associated with LEC2 activity.
Title: LEAFY COTYLEDON2 (LEC2) promotes embryogenic induction in somatic tissues of Arabidopsis, via YUCCA-mediated auxin biosynthesis.
LEC2 alters: (1) the delivery of photosynthates from the seed coat to the embryo, (2) carbon partitioning towards different storage compounds, (3) the rate of starch synthesis, and (4) degradation in developing seeds and germination capacity of dry seeds.
Title: Mutation of the transcription factor LEAFY COTYLEDON 2 alters the chemical composition of Arabidopsis seeds, decreasing oil and protein content, while maintaining high levels of starch and sucrose in mature seeds.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_102595.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of auxin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed oilbody biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic embryogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: AP2/B3-like transcriptional factor family protein

NP_564304.1

LEAFY COTYLEDON 2 (LEC2); CONTAINS InterPro DOMAIN/s: Transcriptional factor B3 (InterPro:IPR003340); BEST Arabidopsis thaliana protein match is: AP2/B3-like transcriptional factor family protein (TAIR:AT3G26790.1); Has 515 Blast hits to 514 proteins in 42 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 515; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

9896867..9899876 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102595.2 → NP_564304.1 AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564304.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0ME96, Q1PFR7, Q93VR5, Q9FZA3

UniProtKB/TrEMBL

A0A654EPA9

Conserved Domains (1) summary

cd10017
Location:170 → 265

B3_DNA; Plant-specific B3-DNA binding domain