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    Gas7 growth arrest specific 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85246, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Gas7provided by RGD
    Official Full Name
    growth arrest specific 7provided by RGD
    Primary source
    RGD:621550
    See related
    EnsemblRapid:ENSRNOG00000049361 AllianceGenome:RGD:621550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and identical protein binding activity. Predicted to be involved in clathrin coat assembly; clathrin-dependent endocytosis; and neuron projection morphogenesis. Predicted to act upstream of or within actin filament organization; neuron differentiation; and regulation of cell shape. Predicted to be located in actin filament and ruffle. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and plasma membrane. Orthologous to human GAS7 (growth arrest specific 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 251.1), Heart (RPKM 71.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gas7 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52651690..52882244)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (52152718..52383283)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (54010723..54240805)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 13 Neighboring gene ATP synthase membrane subunit K, pseudogene 1 Neighboring gene recoverin Neighboring gene glucagon-like peptide 2 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of rat Gas7 isoforms differentially expressed in brain and regulated following kainate-induced neuronal injury. Chang PY, et al. J Neurosci Res, 2005 Mar 15. PMID 15657892
    2. The gas7 protein potentiates NGF-mediated differentiation of PC12 cells. Lortie K, et al. Brain Res, 2005 Mar 2. PMID 15725398
    3. gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. Ju YT, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736752, Free PMC Article
    4. Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis. Liu X, et al. J Cosmet Dermatol, 2024 Jun. PMID 38429909
    5. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. She BR, et al. Exp Cell Res, 2002 Feb 1. PMID 11795944

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.
      Title: Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.
    2. Differential expression and unique regulation of Gas7 isoforms in brain subregions may be important in specialized brain functions. Conservation of Gas7 isoforms by alternative splicing in mammals is also considered.
      Title: Identification of rat Gas7 isoforms differentially expressed in brain and regulated following kainate-induced neuronal injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    growth arrest-specific protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414201.2 → NP_001401130.1  growth arrest-specific protein 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5YBF4, A0A8I5ZM72, A6HFI7
      Related
      ENSRNOP00000079001.1, ENSRNOT00000098305.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52651690..52882244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086994.2 → XP_038942922.1  growth arrest-specific protein 7 isoform X5

      Conserved Domains (2) summary
      cd07649
      Location:91 → 323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:33 → 78
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    2. XM_039086991.2 → XP_038942919.1  growth arrest-specific protein 7 isoform X1

      Conserved Domains (2) summary
      cd07649
      Location:211 → 443
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:153 → 198
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    3. XM_006246828.5 → XP_006246890.1  growth arrest-specific protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9M5, M0RD55
      Related
      ENSRNOP00000088350.1, ENSRNOT00000100512.2
      Conserved Domains (2) summary
      cd07649
      Location:161 → 393
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:67 → 148
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    4. XM_039086995.2 → XP_038942923.1  growth arrest-specific protein 7 isoform X5

      Conserved Domains (2) summary
      cd07649
      Location:91 → 323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:33 → 78
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    5. XM_006246829.5 → XP_006246891.1  growth arrest-specific protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJ10, M0RD55
      Related
      ENSRNOP00000104800.1, ENSRNOT00000126123.1
      Conserved Domains (2) summary
      cd07649
      Location:154 → 386
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:60 → 141
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    6. XM_006246830.5 → XP_006246892.1  growth arrest-specific protein 7 isoform X4

      UniProtKB/TrEMBL
      A6HFI8, M0RD55
      Related
      ENSRNOP00000067551.2, ENSRNOT00000072855.4
      Conserved Domains (2) summary
      cd07649
      Location:150 → 382
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:56 → 137
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    7. XM_039086992.2 → XP_038942920.1  growth arrest-specific protein 7 isoform X5

      Conserved Domains (2) summary
      cd07649
      Location:91 → 323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:33 → 78
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55148.2 GenPept UniProtKB/Swiss-Prot:O55148

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