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    HDAC6 Histone deacetylase 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32461, updated on 17-Dec-2024

    Summary

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    Official Symbol
    HDAC6provided by FlyBase
    Official Full Name
    Histone deacetylase 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0026428
    Locus tag
    Dmel_CG6170
    See related
    AllianceGenome:FB:FBgn0026428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6170; dHDAC2; DHDAC2; dHDAC6; Dmel\CG6170; dmHDA404; DmHDAC2; HDAC; HDAC2; hdac6; hDAC6; Hdac6
    Summary
    Enables histone deacetylase activity. Involved in negative regulation of axon regeneration; neurotransmitter secretion; and regulation of DNA-templated transcription. Located in cytoplasm. Is expressed in adult head and organism. Used to study obesity. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HDAC6 in Genome Data Viewer
    Location:
    13B6-13B6; 1-50 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15333310..15340360)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15227343..15234393)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mir-4957 stem loop Neighboring gene Topoisomerase 1 Neighboring gene discontinuous actin hexagon Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44998 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunosuppression Induced by Brain-Specific HDAC6 Knockdown Improves Aging Performance in Drosophila melanogaster. Zhao Y, et al. Phenomics, 2022 Jun. PMID 36939772, Free PMC Article
    2. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Pandey UB, et al. Autophagy, 2007 Nov-Dec. PMID 17912024
    3. Animal and in silico models for the study of sarcomeric cardiomyopathies. Duncker DJ, et al. Cardiovasc Res, 2015 Apr 1. PMID 25600962, Free PMC Article
    4. Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins. Meijering RA, et al. Front Physiol, 2012. PMID 22375124, Free PMC Article
    5. Human HSPB1 mutation recapitulates features of distal hereditary motor neuropathy (dHMN) in Drosophila. Kang KH, et al. Biochem Biophys Res Commun, 2020 Jan 1. PMID 31630804

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain.
      Title: Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain.
    2. The double-edged sword effect of HDAC6 in Abeta toxicities.
      Title: The double-edged sword effect of HDAC6 in Aβ toxicities.
    3. HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy
      Title: HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy.
    4. that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2
      Title: HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.
    5. HDAC6 is necessary and sufficient for BRP deacetylation. HDAC6 promotes the formation of larger presynaptic densities.
      Title: HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release.
    6. Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin proteostasis and disruption of the cardiomyocyte microtubule structure.
      Title: Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.
    7. From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.
      Title: HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.
    8. Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
      Title: Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.
    9. Data suggest that alpha-synuclein inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.
      Title: Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.
    10. Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.
      Title: Recent strong positive selection on Drosophila melanogaster HDAC6, a gene encoding a stress surveillance factor, as revealed by population genomic analysis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone deacetylase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase 6
    Names
    CG6170-PA
    CG6170-PB
    CG6170-PC
    CG6170-PD
    CG6170-PE
    CG6170-PF
    CG6170-PG
    HDAC6-PA
    HDAC6-PB
    HDAC6-PC
    HDAC6-PD
    HDAC6-PE
    HDAC6-PF
    HDAC6-PG
    histone deacetylase HDA2
    NP_001162760.1
    NP_001245680.1
    NP_001245681.1
    NP_001259569.1
    NP_573017.2
    NP_727842.1
    NP_727843.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15333310..15340360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132789.4 → NP_573017.2  histone deacetylase 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573017.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7E6, C5I7Q8, I1V507, Q86NK9
      Related
      FBpp0073825
      Conserved Domains (3) summary
      cd10002
      Location:119 → 457
      HDAC10_HDAC6-dom1; Histone deacetylase 6, domain 1 and histone deacetylase 10
      cd10003
      Location:538 → 895
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1007 → 1069
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. NM_001272640.1 → NP_001259569.1  histone deacetylase 6, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7E6, C5I7Q8, I1V507, M9PJN5
      Conserved Domains (3) summary
      cd10002
      Location:119 → 457
      HDAC10_HDAC6-dom1; Histone deacetylase 6, domain 1 and histone deacetylase 10
      cd10003
      Location:538 → 895
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1007 → 1069
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. NM_001258751.1 → NP_001245680.1  histone deacetylase 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7E6, C5I7Q8, I1V507, M9NGF7
      Conserved Domains (3) summary
      cd10002
      Location:99 → 437
      HDAC10_HDAC6-dom1; Histone deacetylase 6, domain 1 and histone deacetylase 10
      cd10003
      Location:518 → 875
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:987 → 1049
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    4. NM_167437.2 → NP_727843.1  histone deacetylase 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7E8, C5I7R0, I1V508, Q8IR37
      Related
      FBpp0073826
      Conserved Domains (3) summary
      cd10002
      Location:129 → 467
      HDAC10_HDAC6-dom1; Histone deacetylase 6, domain 1 and histone deacetylase 10
      cd10003
      Location:548 → 905
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1017 → 1079
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    5. NM_167436.3 → NP_727842.1  histone deacetylase 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7E7, C5I7Q9, I1V506, Q8IR38
      Related
      FBpp0073827
      Conserved Domains (3) summary
      cd10002
      Location:126 → 464
      HDAC10_HDAC6-dom1; Histone deacetylase 6, domain 1 and histone deacetylase 10
      cd10003
      Location:545 → 902
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1014 → 1076
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    6. NM_001258752.1 → NP_001245681.1  histone deacetylase 6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245681.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPA9, M9NEH6
      Conserved Domains (2) summary
      cd10002
      Location:126 → 464
      HDAC10_HDAC6-dom1; Histone deacetylase 6, domain 1 and histone deacetylase 10
      cd10003
      Location:545 → 902
      HDAC6-dom2; Histone deacetylase 6, domain 2

    7. NM_001169289.2 → NP_001162760.1  histone deacetylase 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPA9, Q9XYX1
      Conserved Domains (2) summary
      cd10002
      Location:44 → 382
      HDAC10_HDAC6-dom1; Histone deacetylase 6, domain 1 and histone deacetylase 10
      cd10003
      Location:463 → 820
      HDAC6-dom2; Histone deacetylase 6, domain 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEH6 M9NEH6
    M9NGF7 M9NGF7
    M9PJN5 M9PJN5
    Q86NK9 Q86NK9
    Q8IR37 Q8IR37
    Q8IR38 Q8IR38
    Q9XYX1 Q9XYX1

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