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    Pep Protein on ecdysone puffs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45961, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pepprovided by FlyBase
    Official Full Name
    Protein on ecdysone puffsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004401
    Locus tag
    Dmel_CG6143
    See related
    AllianceGenome:FB:FBgn0004401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6143; Dmel\CG6143; p100; pep; PEP; PEP/X4; X4/PEP
    Summary
    Enables single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in regulation of mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Colocalizes with polytene chromosome puff. Is expressed in adult head and adult heart. Used to study alcohol use disorder. Orthologous to human CIZ1 (CDKN1A interacting zinc finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pep in Genome Data Viewer
    Location:
    74E4-74E4; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17638103..17645036, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17631203..17638136, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44567 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nedd4 family interacting protein Neighboring gene Keren

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A unique zinc finger protein is associated preferentially with active ecdysone-responsive loci in Drosophila. Amero SA, et al. Genes Dev, 1991 Feb. PMID 1899840
    2. Cloning of a gene localized and expressed at the ecdysteroid regulated puff 74EF in salivary glands of Drosophila larvae. Möritz T, et al. EMBO J, 1984 Feb. PMID 16453498, Free PMC Article
    3. Measurement of antigen by enhanced chemiluminescent western blot. Huang D, et al. Biotechniques, 1997 Mar. PMID 9067021
    4. A unique ribonucleoprotein complex assembles preferentially on ecdysone-responsive sites in Drosophila melanogaster. Amero SA, et al. Mol Cell Biol, 1993 Sep. PMID 8355684, Free PMC Article
    5. Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure. Zimowska G, et al. Exp Cell Res, 2002 Jun 10. PMID 12027452

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    protein on ecdysone puffs
    Names
    74F gene
    CG6143-PA
    CG6143-PB
    CG6143-PC
    CG6143-PD
    Pep-PA
    Pep-PB
    Pep-PC
    Pep-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17638103..17645036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259888.3 → NP_001246817.1  protein on ecdysone puffs, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEL0, M9NG39
      Conserved Domains (2) summary
      sd00020
      Location:267 → 287
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:193 → 217
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    2. NM_206396.4 → NP_996118.1  protein on ecdysone puffs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996118.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEL0, M9NG39
      Conserved Domains (2) summary
      sd00020
      Location:267 → 287
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:193 → 217
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. NM_080119.6 → NP_524858.1  protein on ecdysone puffs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41073, Q8IGB1, Q8MSV5, Q9VVJ2, Q9VVJ3, Q9VVJ4
      UniProtKB/TrEMBL
      D5AEL0
      Related
      FBpp0074963
      Conserved Domains (2) summary
      sd00020
      Location:290 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:216 → 240
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    4. NM_168742.4 → NP_730290.3  protein on ecdysone puffs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730290.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41073
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NG39 M9NG39
    P41073.1 P41073

    Gene LinkOut

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