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    Fur1 Furin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fur1provided by FlyBase
    Official Full Name
    Furin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004509
    Locus tag
    Dmel_CG10772
    See related
    AllianceGenome:FB:FBgn0004509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10772; dFur1; Dfur1; dFurin 1; Dfurin1; dKLIP-1; Dmel\CG10772; fur-1; fur1; furin; Furin; Furl; fur[1]; Klip1; l(3)rL205
    Summary
    Enables serine-type endopeptidase activity. Involved in synapse organization and synaptic target recognition. Located in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; ganglia; germline cell; gut section; and oenocyte. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including FURIN (furin, paired basic amino acid cleaving enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fur1 in Genome Data Viewer
    Location:
    96D2-96E1; 3-87 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25347431..25473058, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21173153..21298780, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene rha Neighboring gene target of brain insulin Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit-like Neighboring gene uncharacterized protein Neighboring gene astrocytic leucine-rich repeat molecule Neighboring gene Mucin 96D Neighboring gene Vacuolar protein sorting 33B Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A unique Kex2-like endoprotease from Drosophila melanogaster is expressed in the central nervous system during early embryogenesis. Hayflick JS, et al. J Neurosci, 1992 Mar. PMID 1545235, Free PMC Article
    2. An arthropod enzyme, Dfurin1, and a vertebrate furin homolog display distinct cleavage site sequence preferences for a shared viral proprotein substrate. Cano-Monreal GL, et al. J Insect Sci, 2010. PMID 20578951, Free PMC Article
    3. Loss of the Schizophrenia-Linked Furin Protein from Drosophila Mushroom Body Neurons Results in Antipsychotic-Reversible Habituation Deficits. Foka K, et al. J Neurosci, 2022 Sep 28. PMID 36028314, Free PMC Article
    4. Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense. Aittomäki S, et al. FASEB J, 2017 Nov. PMID 28705811
    5. Heritable variation in courtship patterns in Drosophila melanogaster. Gaertner BE, et al. G3 (Bethesda), 2015 Feb 3. PMID 25650358, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Furin1 is a negative regulator of the Janus kinase/signal transducer and activator of transcription signaling pathway, which is implicated in stress responses in the fly. In summary, our data identify Furin1 as a novel regulator of humoral immunity and cellular stress responses in Drosophila
      Title: Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense.
    2. Study demonstrates that Furin proteases are required for Trk cleavage, and show that the Furin 1 and Furin 2 proteases act redundantly in terminal patterning in the Drosophila embryo.
      Title: Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.
    3. alternative PE2 cleavage phenotypes observed in vertebrate and arthropod cells were due to differences in substrate specificity between the arthropod and vertebrate furin
      Title: An arthropod enzyme, Dfurin1, and a vertebrate furin homolog display distinct cleavage site sequence preferences for a shared viral proprotein substrate.
    4. furin-cleavage sites in BMP2/4/DPP precursors are tolerant to mutations acquired through evolution and have adapted to different systems in diversified species
      Title: The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutamate receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    furin 1
    Names
    CG10772-PA
    CG10772-PB
    CG10772-PC
    CG10772-PD
    CG10772-PF
    CG10772-PG
    CG10772-PH
    CG10772-PI
    CG10772-PJ
    Dfurin1
    Fur1-PA
    Fur1-PB
    Fur1-PC
    Fur1-PD
    Fur1-PF
    Fur1-PG
    Fur1-PH
    Fur1-PI
    Fur1-PJ
    Furin-like protease
    Furin1
    furin
    NP_001262953.1
    NP_001262954.1
    NP_001262955.1
    NP_524885.1
    NP_733102.1
    NP_733103.1
    NP_733104.1
    NP_996293.1
    NP_996294.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25347431..25473058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170654.2 → NP_733102.1  furin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30430, Q27235, Q9VBR5
      Related
      FBpp0089025
      Conserved Domains (5) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:943 → 973
      FU; Furin-like repeats
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 785
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    2. NM_001276025.1 → NP_001262954.1  furin 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHV0
      Conserved Domains (5) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1320 → 1350
      FU; Furin-like repeats
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 787
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    3. NM_206571.2 → NP_996294.2  furin 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996294.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26016
      Conserved Domains (4) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 785
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    4. NM_170656.2 → NP_733104.1  furin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26016
      Related
      FBpp0089028
      Conserved Domains (4) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 785
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    5. NM_170655.2 → NP_733103.1  furin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26016
      Related
      FBpp0089027
      Conserved Domains (4) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 785
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    6. NM_080146.3 → NP_524885.1  furin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524885.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3E2, P26016, Q05817, Q27436
      Related
      FBpp0089026
      Conserved Domains (4) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 787
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    7. NM_206570.2 → NP_996293.1  furin 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996293.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26016
      Conserved Domains (4) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 785
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    8. NM_001276024.1 → NP_001262953.1  furin 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI15
      Conserved Domains (4) summary
      cd04059
      Location:332 → 621
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:363 → 646
      Peptidase_S8; Subtilase family
      pfam01483
      Location:701 → 785
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:234 → 309
      S8_pro-domain; Peptidase S8 pro-domain

    9. NM_001276026.1 → NP_001262955.1  furin 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAG0
      Conserved Domains (1) summary
      pfam16470
      Location:234 → 263
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHV0 A0A0B4KHV0
    A0A0B4KI15 A0A0B4KI15
    F0JAG0 F0JAG0
    P26016.2 P26016
    P30430.2 P30430

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