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    Lac Lachesin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36363, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Lacprovided by FlyBase
    Official Full Name
    Lachesinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010238
    Locus tag
    Dmel_CG12369
    See related
    AllianceGenome:FB:FBgn0010238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bulb; CG12369; CT24921; Dmel\CG12369; l(2)k11012; l(2)k11012b; lac
    Summary
    Enables protein homodimerization activity. Involved in several processes, including cell adhesion involved in heart morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of tube architecture, open tracheal system. Located in septate junction. Is expressed in several structures, including anlage in statu nascendi; epithelium; ganglia; glial cell; and head epidermis primordium. Orthologous to human NEGR1 (neuronal growth regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lac in Genome Data Viewer
    Location:
    49A6-49A7; 2-67 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12453190..12465630)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8340695..8353135)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Deubiquitinating apoptotic inhibitor Neighboring gene Transmembrane protein 18 Neighboring gene Dystrobrevin Neighboring gene uncharacterized protein Neighboring gene dim gamma-tubulin 5 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular Evolution and Functional Divergence of the IgLON Family. Kubick N, et al. Evol Bioinform Online, 2018. PMID 29844654, Free PMC Article
    2. Lachesin: an immunoglobulin superfamily protein whose expression correlates with neurogenesis in grasshopper embryos. Karlstrom RO, et al. Development, 1993 Jun. PMID 8223276
    3. Crumbs affects protein dynamics in anterior regions of the developing Drosophila embryo. Firmino J, et al. PLoS One, 2013. PMID 23555600, Free PMC Article
    4. Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper. Stork T, et al. Development, 2009 Apr. PMID 19261699
    5. Atypical septate junctions maintain the somatic enclosure around maturing spermatids and prevent premature sperm release in Drosophila testis. Dubey P, et al. Biol Open, 2019 Feb 4. PMID 30635267, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lac co-localizes with Septate Junction proteins and accumulates specifically at this type of cellular junction.
      Title: Lachesin is a component of a septate junction-based mechanism that controls tube size and epithelial integrity in the Drosophila tracheal system.
    2. Here, we report that Drosophila Lachesin (Lac), a septate junction component, is required for a functional blood brain barrier.
      Title: The IgLON protein Lachesin is required for the blood-brain barrier in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of epithelial integrity, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lachesin
    Names
    CG12369-PA
    Lac-PA
    bulbous
    lachesin bulbous

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12453190..12465630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078989.3 → NP_523713.2  lachesin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523713.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24372, Q86PE5, Q8ML12, Q9V6C2
      Related
      FBpp0087044
      Conserved Domains (4) summary
      smart00410
      Location:36 → 131
      IG_like; Immunoglobulin like
      pfam13927
      Location:134 → 208
      Ig_3; Immunoglobulin domain
      cd00096
      Location:153 → 157
      Ig; Ig strand B [structural motif]
      cl11960
      Location:227 → 318
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24372.2 Q24372

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